Abstract
Exposure to DBTL (20, 40 or 80 mg/kg body weight) caused a decrease in levels of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) at all treatment levels. Hypothalamus and frontal cortex appeared to be most affected, since levels of all the three amines examined showed changes in these areas. Maximum decrease of DA was found in corpus striatum, NA in pons medulla and of 5-HT in frontal cortex. These animals also showed a decrease in spontaneous locomotor activity and learning at all the doses. The data indicates involvement of hypothalamus and frontal cortical regions of the brain in the neurotoxicity of DBTL.
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References
Barnes JJ, Stoner HB (1959) The toxicity of tin compounds. Pharmacol Rev 11: 211–231
Carr HG (1969) Interaction between PVC bottles and liquid foods. Soc Plast Eng 25: 72–74
Chandra SV, Shukla GS, Saxena DK (1979) Manganese induced behavioral dysfunction and its neurochemical mechanisms in growing mice. J Neurochem 33: 1217–1221
Cook L, Weidley E (1956) Behavioural effects of some psychopharmacological agents. Ann NY Acad Sci 66: 740–752
Crow TJ (1977) Neurotransmitter, related pathways. In: Davison AN (ed) The structure and function of central monoamine neurons. Plenum, New York, pp 1–22
David AG, Thomas RB, Bridger WH (1975) The role of catecholamines in animal learning and memory. In: Friedhoff AI (ed) Catecholamines and behavior 2. Plenum, New York, pp 73–104
De Bruin A (1976) Biochemical toxicology of environmental agents. Elsevier North Holland Biomedical Press, Amsterdam, pp 1034–1060
Diwedi RS, Kaur G, Srivastava RC, Srivastava TN (1985) Acute effects of organotin on brain liver and kidney in rats. Indust Health 23: 9–15
Dixit R, Husain R, Mukhtar H, Seth PK (1981) Effect of acrylamide on biogenic amine levels, monoamine oxidase and cathepsin-D activity of rat brain. Environ Res 26: 168–193
Figge K (1972) Migration of additives from plastic films to edible oil and fat simulants. Food Cosmet Toxicol 10: 815–827
Fisher RA (1950) In: Oliver, Boyd (eds) Statistical methods for research workers, 11th ed., London
Glowinski J, Iverson L (1966) Regional studies of catecholamines in the rat brain. I. The deposition of 3H-norepinephrine, 3H-dopamine and 3H-dopa in various regions of the brain. J Neurochem 13: 655–669
Gotter M, Michaelson A (1975) Growth, behaviour and brain catecholamines in lead exposed neonatal rats. Science 187: 359–361
Husain R, Srivastava SP, Seth PK (1985a) Methyl methacrylate induced behavioral and neurochemical disorders in rats. Arch Toxicol 58: 33–36
Husain R, Srivastava SP, Seth PK (1985b) Some behavioral effects of early styrene intoxication in experimental animals. Arch Toxicol 57: 53–55
Jacobwitz DM, Richardson JS (1978) Method for the rapid determination of norepinephrine, dopamine and serotonin in the same brain regions. Pharmacol Biochem Behav 8: 515–519
Kimbrough RD (1976) Toxicity and health effects of selected organotin compounds. A Review. Environ Health Perspect 14: 51–56
Koch J, Figge K (1971) Migration of tin stabilizers from PVC bottles into beer. Zulfar 147 (9)
Kuhn WI, Van Maaner (1961) Central nervous system effects of thalidomide. J Pharmacol Exp Ther 134: 60–68
Lloyd KG, Hornykiewiez O (1975) In: Friedhoff AJ (ed) Catecholamines in regulation of motor function in catecholamines and behaviour, Vol 1. Plenum, New York, pp 41–54
Magee PN, Stoner HB, Barner JM (1957) The experimental production of edema in the central nervous system of the rat by triethyltin compounds. J Pathol Bacteriol 73: 107–124
Mailman RB, Krigman MR, Frye GD, Hanin I (1983) Effects of postnatal trimethyltin or triethyltin treatment on CNS catecholamines GABA and acetylcholine systems in the rat. J Neurochem 40: 1423–1429
Piver WT (1973) Organotin compounds. Industrial applications and biological investigation. Environ Health Perspect 4: 61–79
Reiter L, Kidd K, Heavner G, Ruppert P (1980) Behavioral toxicity of acute and subacute exposure to triethyltin in the rat. Neurotoxicology 2: 97–112
Reiter LW, Ruppert PH (1984) Behavioral Toxicity oft trialkyltin compounds: A review. Neurotoxicology 5: 177–186
Robinson IM (1969) Effects of some organotin compounds on tissue amine levels in rats. Food Cosmet Toxicol 7: 47–52
Stoner HB, Barnes JM, Duff JL (1955) Studies on the toxicity of alkyltin compounds. Br J Pharmacol 10: 16–25
Woggon H, Uhde WJ (1967) Toxicological aspects in the migration of PVC stabilizers into food. Plast Kaut 16: 88
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Alam, M.S., Husain, R., Srivastava, S.P. et al. Influence of di-butyltin dilaurate on brain neurotransmitter systems and behavior in rats. Arch Toxicol 61, 373–377 (1988). https://doi.org/10.1007/BF00334618
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DOI: https://doi.org/10.1007/BF00334618