Statistische Analyse der spasmolytischen Wirkung von Atropin gegenüber verschiedenen Parasympathicomimetica am isolierten Meerschweinchen-Ileum

Summary

Studying the statistical basis of antispasmodic reactions, Brock, Geks and Lorenz had already found that the course of reaction between carbaminoylcholine and atropine is specifically different from that of myotropic reactions. In the case of carbaminoylcholine-atropine, the distribution of the relative antispasmodic effects in the probit net showed an S-shaped deviation from the gradient. The authors examined whether this deviation occurs also with other related pharmacological reactions such as pilocarpine-atropine, acetylcholine-atropine and physostigmineatropine.

1. For the reaction carbaminoylcholine-atropine, this S-shaped deviation is confirmed and explained as a negative excess.

2. The other above-mentioned reactions do not show this deviation.

3. This specific behaviour of the carbaminoylcholine-atropine reaction is elucidated by statistical analysis of the primary data, the spasmodic reaction x and the antispasmodic effect y. The specificity is due to a slight negative excess in the distribution of the values obtained in measuring the antispasmodic effects and in the specific alterations which occur in the distribution during the quotient formation.