Skip to main content
SpringerLink
Log in

The effect of Solanum malacoxylon on rachitic bone lesions in the rat

  • Published:
Naunyn-Schmiedeberg's Archives of Pharmacology Aims and scope Submit manuscript

Summary

The plant Solanum malacoxylon (S.M.) is known to cause severe soft tissue calcifications in cattle and sheep and has recently become of special, interest since it exerts biological actions which resemble those of vitamin D. In order to investigate whether S.M. is capable to improve the rachitic bone changes in vitamin d and phosphate deficient rats, a watery extract of 50, 100 and 200 mg S.M. was fed daily to these animals over a period of 10 days. The width of epiphyseal plates was compared after that time with those of rats treated with 0, 0.225, 0.45 and 0.9 IU of vitamin D3 daily. There was a dose related curative effect of S.M. on the epiphyseal lesions very similar to that of vitamin D3. The hypercalcemic and hyperphosphatemic effect of S.M. was identical to that of vitamin D3. The 25-hydroxy-vitamin D serum levels remained almost undetectable, in the S.M. treated rats as well as in the vitamin D3 treated animals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bliss, C. I., Györgi, P.: The animal vitamin assays. P. Györgi (ed.), Vitamin Methods. New York: Academic Press 1951

    Google Scholar 

  • von Herrath, D., Kraft, D., Offermann, G., Schaefer, K.: Solanum malacoxylon: eine therapeutische Alternative für 1,25-Dihydroxycholecalciferol bei urämischen Calciumstoffwechselstörungen.? Dtsch. med. Wschr. 99, 2407–2409 (1974)

    Google Scholar 

  • von Herrath, D., Schaefer, K., Kraft, D., Offermann, G.: Effect of Solanum malacoxylon on calcium metabolism in experimental uremia and in uremic patients. Vitamin D and problems related to uremic bone disease. Eds. A. W. Norman, K. Schaefer, H. G. Grigoleit, D. v. Herrath., and E. Ritz, pp. 703–708. Berlin-New York: W. de Gruyter 1975

    Google Scholar 

  • Humphreys, D. J.: Studies on the active principle of Solanum malacoxylon. Nature New Biol. 246, 155–157 (1973)

    Google Scholar 

  • Ladizesky, M., Cabrejas, M., Labare, C., Mautalen, C.: Solanum malacoxylon and vitamin D: Comparison of its antirachitic activity and its effect, on the intestinal absorption of calcium in the rat. Acta Endocrin. Panam., 5, 71–78 (1974)

    Google Scholar 

  • Mautalen, C. A.: Mechanism of action of Solanum malacoxylon upon calcium and phosphate metabolism in the rabbit. Endocrinology 90, 563–567 (1972)

    Google Scholar 

  • Moorhead, J. F., Humphreys, D. J., Varghese, Z., Basudde, C. D. K., Jenkins, M. V., Wills, M. R.: Studies on “vitamin D-like action” of Solanum malacoxylon. Vitamin D and problems related to uremic bone disease. Eds. A. W. Norman, K. Schaefer, H. G. Grigoleit, D. v. Herrath, and E. Ritz, pp. 725–730. Berlin-New York: W. de Gruyter 1975

    Google Scholar 

  • Norman, A. W., Henry, H.: The role of the kidney and vitamin D. Metabolism in health and disease Clin. Orthop. 98, 258–287 (1974)

    Google Scholar 

  • O'Donnell, J. M., Smith, M. W.: Vitamin D like action of Solanum malacoxylon on calcium transport by rat intestine. Nature (Lond.) 244, 357–358 (1973)

    Google Scholar 

  • Offermann, G., Dittmar, F.: A direct protein-binding assay for 25-hydroxycholecalciferol in serum. Horm. metab. Res. 6, 534 (1974)

    Google Scholar 

  • Offermann, G., Schaefer, K.: Neue Ergebnisse der Vitamin-D-Forschung. Med. Wschr. 28, 374–382, 447–452, (1974)

    Google Scholar 

  • Uribe, A., Holike, M. F., Jorgensen, N. A., DeLuca, H. F.: Action of Solanum malacoxylon on calcium metabolism in the rat. Biochem. biophys. Res. Commun. 58, 257–262 (1974)

    Google Scholar 

  • Walling, M. W., Kimberg, D. V., Lloyd, W., Wells, H., Proscal, D. A., Norman, A. W.: Solanum glaucophyllum (malacoxylon), an apparent source of a water soluble, functional and structural analogue of 1α,25-dihydroxyvitamin D3. Vitamin D and problems related to uremic bone disease. Eds. A. W. Norman, K. Schaefer, H. G. Grigoleit, D. v. Herrath, and E. Ritz. pp. 717–723. Berlin-New York: W. de Gruyter 1975

    Google Scholar 

  • Wasserman, R. H.: Active vitamin D-like substances in Solanum malacoxylon and other calcinogenic plants. Nutr. Rev. 33, 1–5 (1975)

    Google Scholar 

  • Worker, N. A., Carillo, B. J.: “Enteque seco”, calcification and wasting in graziing animals in the Argentine. Nature (Lond.) 215, 71–73 (1967)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medizinische Klinik und Poliklinik der Freien Universität Berlin, Klinikum Steglitz, Hindenburgdamm 30, D-1000, Berlin 45

    D. Kraft, D. von Herrath, G. Offermann & K. Schaefer

Authors
  1. D. Kraft
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. von Herrath
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Offermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Schaefer
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by the Deutsche Forschungsgemeinschaft.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kraft, D., von Herrath, D., Offermann, G. et al. The effect of Solanum malacoxylon on rachitic bone lesions in the rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 290, 29–33 (1975). https://doi.org/10.1007/BF00499987

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00499987

Key words

Search

Navigation