Summary
Pretreatment of rats with dexamethasone (2.5 μmol/kg, a dose which blocks the release of ACTH from the pituitary gland) abolished the reserpine-mediated increase in cAMP and the increase in the cAMP/cGMP ratio in the adrenal medulla. In contrast, the reserpine-mediated induction of tyrosine hydroxylase (TH) remained unchanged. Hypophysectomy had a similar effect to dexamethasone treatment. Since changes in cAMP and changes in the cAMP/cGMP ratio are not indispensible prerequisites for the subsequent induction of TH, a causal relationship between the two phenomena seems to be excluded.
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Otten, U., Thoenen, H. Lack of correlation between changes in cyclic nucleotides and subsequent induction of tyrosine hydroxylase in rat adrenal medulla. Naunyn-Schmiedeberg's Arch. Pharmacol. 293, 105–108 (1976). https://doi.org/10.1007/BF00498878
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DOI: https://doi.org/10.1007/BF00498878