Summary
Using a hyperosmolar erythrocyte model, the authors studied the effect of changes in red cell deformability on whole blood viscosity and investigated the possibility of using pentoxifylline to modify red cell deformability and whole blood viscosity. In vitro studies reveal a significant correlation between the two parameters in as much as they are inversely proportionate, i.e. viscosity increases as red cell deformability decreases and vice versa. Addition of pentoxifylline improves impaired red cell deformability under hyperosmolar conditions and simultaneously produces a reduction in whole blood viscosity.
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References
Braasch, D.: Red cell deformability and capillary blood flow. Physiol. Rev. 51, 679–701 (1971)
Ehrly, A. M.: Rheologically induced impairement of the vascular microcirculation: A new pathophysiological concept of intermittent claudication. Atti di Angiologia 1, 410–413 (1974)
Ehrly, A. M.: The effect of pentoxifylline on the flow properties of hyperosmolar blood. IRCS Med. Sci. 3, 465 (1975a)
Ehrly, A. M.: Beeinflussung der Verformabarkeit dere Erythrozyten duch Pentoxifyllin. Med. Welt 26, 2300–2301 (1975b)
Ehrly, A. M.: Improvement of the flow properties of blood: A new therapeutical approach in occlusive arterial disease. Angiology 27, 188–196 (1976)
Giombi, A., Burnard, E. D.: Rheology of human foetal blood with reference to hematocrit, plasma viscosity, osmolality and pH. Biorheology 6, 315–328 (1970)
Grigoleit, H.-G., Jacobi, G.: Microrheological effects of the vasoactive compound 3,7-dimethyl-1-(5-oxo-hexyl)-xanthine (pentoxifylline, BL 191). IVth Internat. Symp. Atherosclerosis, Tokyo, Aug. 24–28, 1976
LaCelle, P. L.: Alteration of deformability of the erythrocyte membrane in stored blood. Transfusion 9, 238–245 (1969)
Leonhardt, H., Stelter, I.: Untersuchungen über den Einfluß von Thrombozyten und Temperatur auf die Vollblut- und Plasmaviskosität als Vergleichsmessungen zwischen einem Kapillarund Platte-Kegel-Viskosimeter. Experientia 31, 1179–1181 (1975)
Meiselman, H. J., Merrill, E. W., Gilliland, E. R., Pelletier, G. A., Salzman, E. W.: Influence of plasma osmolarity on the rheology of human blood. J. Appl. Physiol. 22, 772–781 (1967)
Nakao, M.: ATP-requiring phenomena in red cell membranes. Cellular and molecular biology of erythrocytes (N. Yokishawa, M. Rapoport, eds.), pp. 35–54. München: Urban and Schwarzenberg, 1974
Rasmussen, S. N.: Influence of plasma hypertonicity on blood viscosity studies in vitro and in an isolated vascular bed. Acta physiol. Scand. 84, 472–481 (1972)
Schmid-Schönbein, H., Weis, J., Ludwig, H.: A simple method for measuring red blood cell deformability in models of the microcirculation. Blut 26, 368–379 (1973)
Stefanovich, V.: Effect of pentoxifylline on energy rich phosphates in rat's erythrocytes. Res. Comm. Chem. Pathol. Pharmacol. 10, 747–750 (1975)
Weed, R. I., LaCelle, P. L., Merrill, E. W.: Metabolic dependence of red cell deformability. J. Clin. Invest. 48, 795–809 (1969)
Wells, R., Schmid-Schönbein, H.: Red cell deformation and fluidity of concentrated cell suspensions. J. Appl. Physiol. 27, 213–217 (1969)
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Leonhardt, H., Grigoleit, H.G. Effects of pentoxifylline on red blood cell deformability and blood viscosity under hyperosmolar conditions. Naunyn-Schmiedeberg's Arch. Pharmacol. 299, 197–200 (1977). https://doi.org/10.1007/BF00498562
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DOI: https://doi.org/10.1007/BF00498562