Summary
The cholinergic agonists, pilocarpine, physostigmine and nicotine, inhibited the prolactin release induced by morphine in male rats in vivo. Pilocarpine also inhibited the release of prolactin induced by β-endorphin or metoclopramide without affecting the basal and haloperidol-stimulated serum prolactin levels. The inhibitory effect of pilocarpine on the morphine-stimulated release of prolactin was antagonized by concurrent administration of atropine but not by atropine methylnitrate or by mecamylamine, while the inhibition by nicotine was antagonized by mecanylamine but not by atropine. The stimulation of prolactin release by morphine and its reversal by pilocarpine were observed after the administration of haloperidol or α-methyltyrosine. These results suggest that the central cholinergic system exerts an inhibitory influence on the prolactin release induced by morphine or β-endorphin and the cholinergic inhibition is not mediated via catecholaminergic neurons.
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Bhargava, H. N., Way, E. L.: Morphine tolerance and physical dependence: influence of cholinergic agonists and antagonists. Eur. J. Pharmacol. 36, 79–88 (1976)
Bruni, J. F., Van Vugt, D., Marshall, S., Meites, J.: Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormone. Life Sci. 21, 461–466 (1977)
Campbell, M. D., Jaques, S., Jr., Gala, R. R.: The lack of an effect of cholinergic agonists on anterior pituitary prolactin production in vitro. Experientia 34, 1522–1523 (1978)
Carlson, H. E., Briggs, J. E., McCallum, R. W.: Stimulation of prolactin secretion by metoclopramide in the rat. Proc. Soc. Exp. Biol. Med. 154, 475–478 (1977)
Chen, H. J., Meites, J.: Effects of biogenic amines and TRH on release or prolactin and TSH in the rat. Endocrinology 96, 10–14 (1975)
Clemens, J. A., Smalstig, E. B., Sawyer, B. D.: Antipsychotic drugs stimulate prolactin release. Psychopharmacologia 40, 123–127 (1974)
Cocci, D., Santagostino, A., Gil-Ad, I., Ferri, S., Müller, E. E.: Leu-enkephalin-stimulated growth hormone and prolactin release in the rat: comparison with the effect of morphine. Life Sci. 20, 2041–2046 (1977)
Dickerman, S., Clark, J., Dickerman, E., Meites, J.: Effects of haloperidol on serum and pituitary prolactin and on hypothalamic PIF in rats. Neuroendocrinology 9, 332–340 (1972)
Donoso, A. O., Bishop, W., Fawcett, C. P., Krulich, L., McCann, S. M.: Effects of drugs that modify brain monoamine concentration on plasma gonadotropin and prolactin levels in the rat. Endocrinology 89, 774–784 (1971)
Ferland, L., Fuxe, K., Eneroth, P., Gustafsson, J.-A., Skett, P.: Effects of methionine-enkephalin on prolactin release and catecholamine levels and turnover in the median eminence. Eur. J. Pharmacol. 43, 89–90 (1977)
Grandison, L., Guidotti, A.: Regulation of prolactin release by endogenous opiates. Nature 270, 357–359 (1977)
Grandison, L., Meites, J.: Evidence for adrenergic mediation of cholinergic inhibition of prolactin release. Endocrinology 99, 775–779 (1976)
Kato, Y., Chihara, K., Ohgo, S., Imura, H.: Effect of nicotine on the secretion of growth hormone and prolactin in rats. Neuroendocrinology 16, 237–242 (1974)
Kato, Y., Iwasaki, Y., Abe, H., Ohgo, S., Imura, H.: Effects of endorphins on prolactin and growth hormone secretion in rats. Proc. Soc. Exp. Biol. Med. 158, 431–436 (1978)
Lawson, D. M., Gala, R. R.: The influence of adrenergic, dopaminergic, cholinergic and serotonergic drugs on plasma prolactin levels in ovariectomized, estrogen-treated rats. Endocrinology 96, 313–318 (1975)
Lu, K.-H., Amenomori, Y., Chen, C.-L., Meites, J.: Effects of central acting drugs on serum and pituitary prolactin levels in rats. Endocrinology 87, 667–672 (1970)
MacLeod, R. M., Lehmeyer, J. E.: Studies on the mechanism of the dopamine-mediated inhibition of prolactin secretion. Endocrinology 94, 1077–1085 (1974)
Müller, E. E., Nistico, G., Scapagnini, U.: Brain neurotransmitters in the control of prolactin secretion. In: Neurotransmitters and anterior pituitary function, pp. 278–291. New York: Academic Press 1977
Muraki, T., Tokunaga, Y.: Effects of morphine on the serum prolactin levels of morphine-tolerant and nontolerant male rats and on the in vitro release of pituitary prolactin. Jap. J. Pharmacol. 28, 803–810 (1978)
Nemeroff, C. B., Bissette, G., Greeley, G. H., Mailman, R. B., Martin, J. B., Brazeau, P., Kizer, J. S.: Effects of acute administration of monosodium L-glutamate (MSG), atropine or haloperidol on anterior pituitary hormone secretion in the rat. Brain Res. 156, 198–201 (1978)
Oka, T., Negishi, K.: Effect of neurohumoral modulators on the morphine-induced hyperthermia in non-tolerant rats. Eur. J. Pharmacol. 42, 225–229 (1977)
Peringer, E., Jenner, P., Donaldson, I. M., Marsden, C. D.: Metoclopramide and dopamine receptor blockade. Neuropharmacology 15, 463–469 (1976)
Quijada, M., Illner, P., Krulich, L., McCann, S. M.: The effect of catecholamines on hormone release from anterior pituitaries and ventral hypothalami incubated in vitro. Neuroendocrinology 13, 151–163 (1973/74)
Shaar, C. J., Frederickson, R. C. A., Dininger, N. B., Jackson, L.: Enkephalin analogues and naloxone modulate the release of growth hormone and prolactin — Evidence for regulation by endogenous opioid peptide in brain. Life Sci. 21, 853–860 (1977)
Sharkawi, M.: Morphine hyperthermia in the rat: its attenuation by physostigmine. Br. J. Pharmacol. 44, 544–548 (1972)
Snedecor, G. W., Cochran, W. G.: Statistical methods, 6th ed., p. 115. Ames: The Iowa State University Press 1967
Subramanian, M. G., Gala, R. R.: The influence of cholinergic, adrenergic, and serotonergic drugs on the afternoon surge of plasma prolactin in ovariectomized, estrogen-treated rats. Endocrinology 98, 842–848 (1976a)
Subramanian, M. G., Gala, R. R.: Further studies on the effects of adrenergic, serotonergic and cholinergic drugs on the afternoon surge of plasma prolactin in ovariectomized, estrogen-treated rats. Neuroendocrinology 22, 240–249 (1976b)
Subramanian, M. G., Gala, R. R.: Specificity of arecoline and apomorphine and the site of action of arecoline in inhibiting the diurnal prolactin surge. Proc. Soc. Exp. Biol. Med. 155, 353–356 (1977)
Takahara, J., Kageyama, J., Yunoki, S.,Yakushiji, W., Yamauchi, J., Kageyama, N. Ofuji, T.: Effects of 2-bromo-α-ergocryptine on β-endorphin-induced growth hormone, prolactin and luteinizing hormone release in urethane anesthetized rats. Life Sci. 22, 2205–2208 (1978)
Tolis, G., Hickey, J., Guyda, H.: Effects of morphine on serum growth hormone, cortisol, prolactin and thyroid stimulating hormone in man. J. Clin. Endocrinol. Metab. 41, 797–800 (1975)
Van Vugt, D. A., Bruni, J. F., Meites, J.: Naloxone inhibition of stress-induced increase in prolactin secretion. Life Sci. 22, 85–90 (1970)
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Muraki, T., Tokunaga, Y., Nakadate, T. et al. Inhibition by cholinergic agonists of the prolactin release induced by morphine. Naunyn-Schmiedeberg's Arch. Pharmacol. 308, 249–254 (1979). https://doi.org/10.1007/BF00501389
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DOI: https://doi.org/10.1007/BF00501389