Summary
The optical isomers of two nifedipine-like 1,4-dihydropyridine derivates have been synthesised and tested in vitro. The (−)-isomer (S-configuration of both compounds) was more potent than the racemate, which in turn was more potent than the (+)-isomer (R-configuration). The S-configuration isomers are approximately ten times more potent than nifedipine, and may represent the optimal structure and configuration for binding to and inhibiting calcium channels.
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References
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Towart, R., Wehinger, E. & Meyer, H. Effects of unsymmetrical ester substituted 1,4-dihydropyridine derivatives and their optical isomers on contraction of smooth muscle. Naunyn-Schmiedeberg's Arch. Pharmacol. 317, 183–185 (1981). https://doi.org/10.1007/BF00500079
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DOI: https://doi.org/10.1007/BF00500079