Abstract
The basal magnocellular nucleus is assumed to play a crucial role in cholinergic activation of the cortical EEG. The aim of this study was to establish whether intraperitoneally applied nicotine may counteract the power asymmetry of the slow waves in the cortical EEG of both hemispheres after an unilateral lesion in the basal nucleus. In 17 rats the basal nucleus (substantia innominata/ventral pallidum) was unilaterally lesioned by ibotenic acid. The lesion produced unilateral power increases of all frequencies up to 20 Hz in the frontal EEG that increased with higher arousal level. Additionally, synchronized spike and wave discharges appeared in the frontal EEG. The results indicate that the basal nucleus suppresses especially the delta EEG waves in the frontal motor cortex during motor active behaviour. Nicotine (0.1 and 1 mg/kg) partially counteracts the power asymmetry of frontal slow waves (2–6 Hz) only during exploratory sniffing but not during grooming and waking immobility. Physostigmine (1 mg/kg) was also effective during exploratory sniffing. The results may indicate a role of nicotinic mechanisms in the information input component of exploratory behaviour.
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References
Abdulla FA, Calaminici MR, Stephenson JD, Sinden JD (1994) Unilateral AMPA lesions of nucleus basalis magnocellularis induce a sensorimotor deficit which is differentially altered by arecoline and nicotine. Behav Brain Res 60:161–169
Acri JB, Grunberg NE, Morse DE (1991) Effects of nicotine on the acoustic startle reflex amplitude in rats. Psychopharmacology 104:244–248
Araujo DM, Lapchak PA, Robitaille Y, Gauthier S, Quirion R (1988) Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease. J Neurochem 50:1914–1923
Beck F, Eccles JC (1992) Quantum aspects of brain activity and the role of consciousness. Proc Natl Acad Sci USA 89:11357-M361
Brazell MP, Mitchell SN, Gray JA (1991) Effect of acute administration of nicotine on in vivo release of noradrenaline in the hippocampus of freely moving rats: a dose-response and antagonist study. Neuropharmacology 8:823–833
Bringmann A (1995) Topographic mapping of the cortical EEG power in the unrestrained rat: peripheral effects of neuroactive drugs. Arch Ital Biol 133:1–16
Buccafusco JJ, Jackson WJ (1991) Beneficial effects of nicotine administered prior to a delayed matching-to-sample task in young and aged monkeys. Neurobiol Aging 12:233–238
Buzsäki G, Bickford RG, Ponomareff G, Thal LJ, Mandel R, Gage FH (1988) Nucleus basalis and thalamic control of neocortical activity in the freely moving rat. J Neurosci 8:4007–4026
Buzsäki G, Gage FH (1989) The cholinergic nucleus basalis: a key structure in neocortical arousal. In: Frotscher M, Misgeld U (eds) Central cholinergic synaptic transmission. Birkhäuser, Basel, PP 159–171
Coben LA, Danzinger WL, Storandt M (1985) A longitudinal EEG study of mild senile dementia of Alzheimer type: changes at 1 year and 2.5 years. Electroencephalogr Clin Neurophysiol 61:101–112
Dunnett SB, Toniolo G, Fine A, Ryan CN, Björklund A, Iversen SD (1985) Transplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis-11. Sensorimotor and learning impairments. Neuroscience 16:787–797
Dunnett SB, Whishaw IQ, Jones GH, Bunch ST (1987) Behavioural, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats. Neuroscience 20:653–669
Dunnett SB, Everitt BJ, Robbins TW (1991) The basal forebrain —cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions. Trends Neurosci 14:494–501
Eccles JC (1994) How the self controls its brain. Springer, Berlin Heidelberg New York
Elrod K, Buccafusco JJ (1988) Selective central nicotinic receptor blockade inhibits passive, but not active, avoidance learning in rats (abstract). Soc Neurosci 18th Ann Mtg, p57
Elrod K, Buccafusco JJ (1991) Correlation of the amnestic effects of nicotinic antagonists with inhibition of regional brain acetylcholine synthesis in rats. J Pharmacol Exp Ther 258:403–409
Ferger B, Kuschinsky K (1994) Activation of dopamine D1 receptors or alpha-1 adrenoceptors is not involved in the EEG effect of nicotine in rats. Naunyn-Schmiedeberg's Arch Pharmacol 350:346–351
Hodges H, Allen Y, Sinden J, Lantos PL, Gray JA (1991) Effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system — 11. Cholinergic drugs as probes to investigate lesion-induced functional recovery. Neuroscience 45:609–623
Jibu M, Hagan S, Hameroff SR, Pribram KH, Yasue K (1994) Quantum optical coherence in cytoskeletal microtubules-implications for brain function. Biosystems 32:195–209
Karnovsky JM, Roots LA (1964) A “direct-coloring” thiocholine method for cholinesterases. J Histochem Cytochem 12:219–221
LoConte G, Casamenti F, Bigl V, Milaneschi E, Pepeu G (1982) Effect of magnocellular forebrain nuclei lesions on acetylcholine output from the cerebral cortex, electrocorticogram and behaviour. Arch Ital Biol 120:176–188
Luiten PGM, Gaykema RPA, Traber J, Spencer DG Jr (1987) Cortical projection patterns of magnocellular basal nucleus subdivisions as revealed by anterogradely transported Phaseolus vulgaris leucoagglutinin. Brain Res 413:229–250
Meyer EM, Arendash GW, Judkins JH, Ying L, Wade C, Kern WR (1987) Effects of nucleus basalis lesions on the muscarinic and nicotinic cholinergic modulation of [3H]-acetylcholine release in the rat cerebral cortex. J Neurochem 49:1758–1762
Müller G, Richter RA, Weisbrod S, Klingberg F (1990) Labyrinth learning impairment in patients with early symptoms of presenile dementia. Gerontology 36:145–149
Nordberg A, Winblad B (1986) Reduced number of [3H] nicotinic and [3H] acetylcholine binding sites in the frontal cortex of Alzheimer brains. Neurosci Lett 72:115–199
Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic Press, New York
Penttilä M, Partanen J, Soininen H, Riekkinen P (1985) Quantitative analysis of occipital EEG in different stages of Alzheimer's disease. Electroenceph Clin Neurophysiol 60:1–6
Riekkinen P, Buzsáki G, Riekkinen Jr P, Soininen H, Partanen J (1990) The cholinergic system and EEG slow waves. Electroenceph Clin Neurophysiol 78:89–96
Sahakian B, Jones G, Levy R, Gray J, Warburton D (1989) The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer type. Br J Psychiatry 154:797–800
Schröder H, Giacobini E, Struble RG, Luiten PGM, Zee EA van der, Zilles K, Strosberg AD (1991) Muscarinic cholinoceptive neurons in the frontal cotex in Alzheimer's disease. Brain Res Bull 27:631–636
Semba K (1991) The cholinergic basal forebrain: a critical role in cortical arousal. In: Napier TC, Kalivas PW, Hanin I (eds) The basal forebrain. Anatomy to function. Plenum, New York PP 197–218
Stewart DJ, MacFabe DF, Vanderwolf CH (1984) Cholinergic activation of the electrocorticogram: role of the substantia innominata and effects of atropine and quinuclidinyl benzilate. Brain Res 322:219–232
Tilson HA, McLamb RL, Shaw S, Rodgers BC, Pediaditakis P, Cook L (1988) Radial-arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agents. Brain Res 438:83–94
Yoshida K, Kato Y, Imura H (1980) Nicotine-induced release of noradrenaline from hypothalamic synaptosomes. Brain Res 182:361–368
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Bringmann, A. Behaviour-related effects of nicotine on slow EEG waves in basal nucleus-lesioned rats. Naunyn-Schmiedeberg's Arch Pharmacol 353, 168–174 (1996). https://doi.org/10.1007/BF00168754
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DOI: https://doi.org/10.1007/BF00168754