Abstract
Adult rats, required to perform a motor coordination task while under the influence of ethanol (2.2 g/kg) daily for 12 days, developed significant tolerance to the effects of ethanol, not only on this test but also on a food-motivated maze task. At the same time, they showed reduced shock threshold for production of a startle response, and reduced open field test scores 23 hrs after the last dose of ethanol. Other animals receiving the same dose of ethanol immediately after each training session on the coordination task, and others performing the task and receiving no ethanol, showed no tolerance on either test and no change in shock threshold or open field behavior. The results suggest that behaviorally augmented tolerance depends on basic neuronal adaptive changes indistinguishable from those accompanying physiological tolerance and dependence.
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Carder, B., Olson, J.: Learned behavioral tolerance to marihuana in rats. Pharmacol. Biochem. Behav. 1, 73–76 (1973)
Chen, C.-S.: A study of the alcohol tolerance effect and an introduction of a new behavioral technique. Psychopharmacologia (Berl.) 12, 433–440 (1968)
Eysenck, H. J., Broadhurst, P. L.: In: Experiments in motivation, H. J. Eysenck (ed.), p. 285. New York: MacMillan 1964
Gibbins, R. J., Kalant, H., LeBlanc, A. E.: Technique for accurate measurement of moderate degrees of alcohol intoxication in small animals. J. Pharmacol. exp. Ther. 159, 236–242 (1968)
Gibbins, R. J., Kalant, H., LeBlanc, A. E., Clark, J. W.: The effects of chronic administration of ethanol on startle thresholds in rats. Psychopharmacologia (Berl.) 19, 95–104 (1971)
Kalant, H., LeBlanc, A. E., Gibbins, R. J.: Tolerance to, and dependence on, some non-opiate psychotropic drugs. Pharmacol. Rev. 23, 135–191 (1971)
LeBlanc, A. E.: Behavioral and pharmacological variables in the development of ethanol tolerance. Ph. D. Thesis, University of Toronto, Toronto, Canada (1972)
LeBlanc, A. E., Gibbins, R. J., Kalant, H.: Behavioral augmentation of tolerance to ethanol in the rat. Psychopharmacologia (Berl.) 30, 117–122 (1973)
LeBlanc, A. E., Kalant, H., Gibbins, R. J.: Acute tolerance to ethanol in the rat. Psychopharmacologia (Berl.) 41, 43–46 (1975)
LeBlanc, A. E., Kalant, H., Gibbins, R. J., Berman, N. D.: Acquisition and loss of tolerance to ethanol by the rat. J. Pharmacol. exp. Ther. 168, 244–250 (1969)
Wahlström, G.: Differences in tolerance to hexobarbital (enhexymalum NFN) after barbital (diemalum NFN) pre-treatment during activity or rest. Acta pharmacol. (Kbh.) 26, 92–104 (1968)
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Leblanc, A.E., Gibbins, R.J. & Kalant, H. Generalization of behaviorally augmented tolerance to ethanol, and its relation to physical dependence. Psychopharmacologia 44, 241–246 (1975). https://doi.org/10.1007/BF00428900
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DOI: https://doi.org/10.1007/BF00428900