Summary
The chronic administration of ECS leads to a decrease of H3-NE in all parts of the brain, and an increase in dihydroxymandelic acid, dihydroxyphenylglykol, methoxy-hydroxymandelic acid, and methoxy-hydroxyphenylglykol. In the hypothalamus and the cerebellum there is also an increase in normetanephrine, which is not observable in the other parts of the brain.
Uptake experiments in vitro showed a lower uptake of H3-NE in brain homogenates of ECS animals.
ECS in combination with DMI-treatment did not increase the NM-values whereas combination of ECS with lithium led to an increase of DH compounds and a corresponding decrease of NM.
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We thank Mrs. T. Grupe and Miss A. Renz for their efficient and accurate technical assistance.
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Ladisich, W., Steinhauff, N. & Matussek, N. Chronic administration of electroconvulsive shock and norepinephrine metabolism in the rat brain. Psychopharmacologia 15, 296–304 (1969). https://doi.org/10.1007/BF00401684
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DOI: https://doi.org/10.1007/BF00401684