Abstract
The influence of α-methyl tyrosine and diethyldithiocarbamate which specifically inhibit noradrenaline synthesis and the influence of p-chlorophenylalanine which inhibits 5-hydroxytryptamine synthesis in the brain on the antagonism between desmethylimipramine and RO 4-1284 was studied. It was shown that both substances which inhibit noradrenaline synthesis abolish the behavioural antagonism between DMI and RO 4-1284, and p-chlorophenylalanine is without effect on this antagonism. The evidence shows that DMI antagonises the action of a benzoquinolizine derivative by the participation of adrenergic mechanisms.
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Herman, Z.S. Studies on adrenergic mechanisms in the action of desmethyl imipramine (DMI). Psychopharmacologia 17, 234–241 (1970). https://doi.org/10.1007/BF00402083
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DOI: https://doi.org/10.1007/BF00402083