Abstract
The influence of alprenolol and amphetamine alone or combined on the content of noradrenaline, dopamine and 5-hydroxytryptamine in seven discrete areas of the brain and on rat behaviour was studied. Animals were treated with drugs for 6 months. Alprenolol caused mainly a decrease of the estimated endogenous amines in different brain areas. Amphetamine caused a decrease of all three amines in some parts of the brain, and reversed some of the changes caused by alprenolol. Alprenolol had no effect on the locomotor activity of rats, but increased the activity of rats treated with amphetamine after the first week of treatment, and antagonized the excitatory effect caused by amphetamine during the following weeks of the experiment.
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Baird, J. R. C.: The effects of (+) amphetamine and (±) phenmetrazine on the noradrenaline and dopamine levels in the hypothalamus and corpus striatum of the rat. J. Pharm. Pharmacol. 20, 234–235 (1968).
Brodie, B., Beaven, M. A.: Neurochemical transducer systems. Med. exp. (Basel) 8, 320–352 (1963).
Chang, C. C.: A sensitive method for spectrophotofluorometric assay of catecholamines. Int. J. Neuropharmacol. 3, 643–649 (1964).
Dewhurst, W. G.: New theory of cerebral amine function and its clinical application. Nature (Lond.) 218, 1130–1133 (1968).
Falckenberg, B., Gerbert, K.: Effect of the β-adrenolytic substance 1-(isopropylamino)-3-(m-tolyloxy)-2-propanol hydrochloride (Kö 592) on Psychic capacity functions. Arzenimittal-Forsch. 18, 1047–1051 (1968).
Fitzgerald, J. D.: Perspectives in adrenergic beta-receptor blockade. Clin. Pharmacol. Ther. 10, 292–306 (1969).
Foo, J. W., Jowett, A., Stafford, A.: The effects of some β-adrenoreceptor blocking drugs on the uptake and release of noradrenaline by the heart. Brit. J. Pharmacol. 34, 141–147 (1968).
Glowinski, J., Baldessarini, R. J.: Metabolism of norepinephrine in the centra nervous system. Pharmacol. Rev. 18, 1201–1238 (1966).
Gunne, L.-M., Lewander, T.: Brain catecholamines during chronic amphetamine intoxication. In: The addictive states. Association for research in Nervous and mental disease, Vol. XLVI, p. 106. Baltimore: Williams and Wilkins 1968.
Herman, Z. S.: The effects of noradrenaline on rat's behaviour. Psychopharmacologia (Berlin) 16, 369–374 (1970).
Knoll, J.: Motimeter, a new sensitive apparatus for the quantitative measurement of hypermotility caused by psychostimulants. Arch. int. Pharmacodyn. 120, 141–154 (1961).
Laverty, R., Taylor, K. M.: Propranolol uptake into the central nervous system and the effect on rat behaviour and amine metabolism. J. Pharm. Pharmacol. 20, 605–609 (1968).
Maickel, R. P., Cox, R. H., Saillant, J., Miller, F. P.: A method for the determination of serotonin and norepinephrine in discrete areas of rat brain. Int. J. Neuropharmacol. 7, 275–281 (1968).
Mantegazza, P., Naimzada, K. M., Riva, M.: Effects of propranolol on some activities of amphetamine. Europ. J. Pharmacol. 4, 25–30 (1968).
Matsumoto, J., Watanabe, S.: Paradoxical sleep: effects of adrenergic blocking agents. Proc. Jap. Acad. 43, 680–683 (1967).
McLean, J. R., Mc Cartney, M.: Affect of d-amphetamine on rat nor-adrenaline and serotonin. Proc. Soc. exp. Biol. (N.Y.) 107, 77–79 (1961).
Miller, F. P., Cox, R. H., Jr., Snodgrass, W. R., Maickel, R. P.: Comparative effects of p-chlorophenylalanine, p-chloramphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid. Biochem. Pharmacol. 18, 435–442 (1969).
Moore, K. E.: The role of endogenous norepinephrine in the toxicity of d-amphetamine in aggregated mice. J. Pharmacol. exp. Ther. 144, 45–51 (1964).
—, Lariviere, E. W.: Effects of d-amphetamine and restraint on the content of norepinephrine and dopamine in rat brain. Biochem. Pharmacol. 12, 1283–1288 (1963).
Murmann, W., Almirante, L., Saccani-Guelfi, M.: Central nervous system effects of four β-adrenergic receptor blocking agents. J. Pharm. Pharmacol. 18, 317–318 (1966).
Smith, C. B.: Effect of d-amphetamine upon brain content and locomotor activity of mice. J. Pharmacol. exp. Ther. 147, 96–102 (1965).
Tissot, R.: Monoamines et système nerveux central. Paris: G. Doin and Cie (1961).
Vogt, M.: Release from brain tissue of compounds with possible transmitter function: interaction of drugs with these substances. Brit. J. Pharmacol. 37, 325–337 (1969).
Westfall, T. C.: Accumulation of norepinephrine in rat tissues following treatment with three beta-adrenergic antagonists. Arch. int. Pharmacodyn. 167, 69–79 (1967).
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Herman, Z.S., Kmieciak-Kołada, K., Drybański, A. et al. The influence of 1-(o-Allylphenoxy)-3-Isopropylamino-2-Propanol Hydrochloride (Alprenolol) on the central nervous system of the rat. Psychopharmacologia 21, 66–73 (1971). https://doi.org/10.1007/BF00403997
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DOI: https://doi.org/10.1007/BF00403997