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Norepinephrine metabolism in the rat brain following acute and chronic administration of thyrotropin releasing hormone

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Abstract

Synthetic thyrotropin releasing hormone (TBH) was administered to albino rats in order to determine the effects of this drug on norepinephrine-H3 metabolism in the brain. With the possible exception of a slight enhancement of release, acute or chronic administration of TRH had little effect on the disposition and metabolism of norepinephrine-H3 in rat brain. In addition, no significant changes were found in brain levels of endogenous norepinephrine, serotonin or dopamine following the injection of TRH. Thus, little evidence was found to support a possible relationship between the reported clinical antidepressant activity of TRH and its effects on norepinephrine metabolism in brain.

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References

  • Anton, A. H., Sayre, D. F.: A study of the factors affecting aluminum oxidetrihydroxyindole procedure for the analysis of catecholamines. J. Pharmacol. exp. Ther. 138, 360–370 (1962)

    Google Scholar 

  • Breese, G. R., Cooper, B. R., Prange, A. J., Jr., Cott, J. M., Lipton, M. A.: Interactions of the thyrotropin releasing hormone (TRH) with centrally acting drugs. In: The thyroid axis, drugs and behavior. A. J. Prange, Jr., Ed. New York: Raven Press (in press)

  • Carlsson, A., Waldeck, B.: A fluorimetric method for the determination of dopamine (3-hydroxytyramine). Acta physiol. scand. 44, 293–298 (1958)

    Google Scholar 

  • Kastin, A. J., Ehrensing, R. H., Schalen, D. S., Anderson, M. S.: Improvement in mental depression with decreased thyrotropin response after administration of thyrotropin-releasing hormone. Lancet 1972 II, 740–742

    Google Scholar 

  • Plotnikoff, N. P., Prange, A. J., Jr., Breese, G. R., Anderson, M. S., Wilson, I. C.: Thyrotropin releasing hormone: Enhancement of dopa activity by a hypothalamic hormone. Science 178, 417–418 (1972)

    Google Scholar 

  • Plotnikoff, N. P., Prange, A. J., Jr., Breese, G. R., Anderson, M. S., Wilson, I. C.: The effects of thyrotropin releasing hormone in normal, hypophysectomized, and thyroidectomized animals. In: The thyroid axis, drugs and behavior. A. J. Prange, Jr., Ed. New York: Raven Press (in press)

  • Prange, A. J., Jr., Wilson, I. C.: Thyrotropin-releasing hormone (TRH) for the immediate relief of depression: A preliminary report. Psychopharmacologia (Berl.) Suppl. 26, 82 (1972)

    Google Scholar 

  • Prange, A. J., Jr., Wilson, I. C., Lara, P. P., Alltop, L. B., Breese, G. R.: Effects of thyrotropin-releasing hormone in depression. Lancet 1972 II, 999–1002

    Google Scholar 

  • Sandler, M., Goodwin, B. L., Leask, B. G. S., Ruthven, C. R. J.: Melanocyte-stimulating hormone and Parkinsonism: The role of hypothalamic releasing factors. Lancet 1973 I, 612

    Google Scholar 

  • Schanberg, S. M., Schildkraut, J. J., Kopin, I. J.: The effects of pentobarbital on the fate of intracisternally administered norepinephrine-H3. J. Pharmacol. exp. Ther. 157, 311–318 (1967)

    Google Scholar 

  • Schildkraut, J. J.: Neuropsychopharmacology and the affective disorders. Boston: Little, Brown and Comp. 1970a

    Google Scholar 

  • Schildkraut, J. J.: Tranylcypromine: Effects on norepinephrine metabolism in rat brain. Amer. J. Psychiat. 126, 925–931 (1970b)

    Google Scholar 

  • Schildkraut, J. J., Schanberg, S. M., Breese, G. R., Kopin, I. J.: Norepinephrine metabolism and drugs used in the affective disorders: A possible mechanism of action. Amer. J. Psychiat. 124, 600–608 (1967)

    Google Scholar 

  • Snyder, S. H., Axelrod, J., Zweig, M.: A sensitive and specific fluorescence assay for tissue serotonin. Biochem. Pharmacol. 14, 831–835 (1965)

    Google Scholar 

  • Tuomisto, J., Mannisto, P.: Amine uptake and thyrotropin-releasing hormone. Lancet 1973 I, 836

    Google Scholar 

  • Van der Vis-Melsen, M. J. E., Wiener, J. D.: Improvement in mental depression with decreased thyrotropin response after administration of thyrotropinreleasing hormone. Lancet 1972 II, 1415

    Google Scholar 

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Authors and Affiliations

  1. Neuropsychopharmacology Laboratory, Massachusetts Mental Health Center, Boston, Massachusetts

    Thomas G. Reigle, Jacob Avni, Patricia A. Platz & Joseph J. Schildkraut

  2. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts

    Thomas G. Reigle, Jacob Avni, Patricia A. Platz & Joseph J. Schildkraut

  3. Experimental Therapy Division, Abbott Laboratories, North Chicago, Illinois

    Nicholas P. Plotnikoff

Authors
  1. Thomas G. Reigle
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  2. Jacob Avni
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  3. Patricia A. Platz
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  4. Joseph J. Schildkraut
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  5. Nicholas P. Plotnikoff
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Reigle, T.G., Avni, J., Platz, P.A. et al. Norepinephrine metabolism in the rat brain following acute and chronic administration of thyrotropin releasing hormone. Psychopharmacologia 37, 1–6 (1974). https://doi.org/10.1007/BF00426676

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  • DOI: https://doi.org/10.1007/BF00426676

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