Abstract
The behavioural effects of a range of high doses of D-amphetamine and DL-fenfluramine were investigated in rats. Subjects were observed individually for 1 min in every 5 for a period of an hour. During each observation period the presence of any of 6 behavioural patterns was recorded in an “all or none”; fashion Behaviour patterns recorded included: Rearing, Forward Locomotion, Immobility, Backward Locomotion, Circling and Head Swaying. The last 3 behaviours are considered “Abnormal”; in that they were never observed in saline treated controls. The results indicate that, at the doses used in this study, both compounds induce abnormal behaviours, the latency of onset of which is directly proportional to dose. For both compounds an inverse correlation was found between normal and abnormal behaviours. However, the type of abnormal behaviour observed differed considerably between drugs in that fenfluramine elicited Backward Walking and Circling with no Head Swaying, over the dose range 10–30 mg per kg; whilst the predominant abnormal behaviour elicited by D-amphetamine, over the range 5–20 mg per kg, was Head Swaying. At the highest doses of amphetamine used some Backward Walking was elicited, behaviour which was totally absent at the lower doses. The implications of these results for the concept of “stereotypy”; are discussed, and attention is drawn to an important distinction between abnormal and stereotyped behaviour.
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References
Angrist, B. M., Gershon, S.: The phenomenology of experimentally induced amphetamine psychosis. Biol. Psychiat. 2, 95–107 (1970)
Angrist, B., Sathananthan, G., Gershon, S.: Behavioural effects of l-Dopa in schizophrenic patients. Psychopharmacologia (Berl.) 31, 1–12 (1973)
Arnfeld, T., Randrup, A.: Cholinergic mechanisms in brain inhibiting amphetamine induced behaviour. Acta pharmacol. (Kbh.) 26, 384–394 (1968)
Ashcroft, G. W., Eccleston, D., Wadell, J. L.: Recognition of amphetamine addicts. Brit. med. J. 1965 I, 57
Bell, D. S.: The experimental reproduction of amphetamine psychosis. Arch. gen. Psychiat. 29, 35–40 (1973)
Borberg, S.: Conditioning of amphetamine-induced abnormal behaviour. Psychopharmacologia (Berl.) 34, 191–198 (1974)
Campbell, D. B.: Absorption, distribution and metabolism of fenfluramine. Vie Med. au Canada Francais 2, 34–60 (1973)
Costa, E., Gropetti, B., Revuelta, A.: Action of fenfluramine on monoamine stores of rat tissues. Brit. J. Pharmacol. 41, 57–64 (1971)
Costa, E., Revuelta, A.: Norfenfluramine and serotonin turnover rate in the rat brain. Biochem. Pharmacol. 21, 2385–2393 (1972)
Dandiya, P. C., Gupta, B. D., Gupta, M. L., Patni, S. K.: Effects of L.S.D. on open field performance in rats. Psychopharmacologia (Berl.) 15, 337–340 (1969)
Del Rio, J., Fuentes, J. A.: Further studies of the antagonism of stereotyped behaviour induced by amphetamine. Europ. J. Pharmacol. 8, 73–78 (1969)
Dixon, A. K.: Evidence of catecholamine mediation in the Aberrant behaviour induced by Lysergic Acid Diethylamide (LSD) in the rat. Experientia (Basel) 24, 743–747 (1968)
Ellinwood, E. H., Sudilovsky, A., Nelson, L.: Behavioural analysis of chronic amphetamine intoxication. Biol. Psychiat. 4, 215–230 (1972)
Ernst, A. M.: Mode of action of apomorphine and dexamphetamine on Gnawing compulsion in rats. Psychopharmacologia (Berl.) 10, 316–323 (1967)
Fog, R.: Stereotyped and non-stereotyped behaviour in rats induced by various stimulant drugs. Psychopharmacologia (Berl.) 14, 299–304 (1969)
Goudie, A. J., Taylor, M.: Time sampling of rat exploratory behaviour: A reliable screening test for the C.N.S. Effects of anorexic agents. Psychopharmacologia (Berl.) 35, 1–12 (1974)
Goudie, A. J., Taylor, M., Wheeler, T. J.: Chronic anorexic and behavioural effects of the fenfluramine metabolite, norfenfluramine: An evaluation if its role in the actions of fenfluramine. Psychopharmacologia (Berl.) 38, 67–74 (1974)
Janssen, P. A. J., Niemegeers, C. J. E., Schellekens, K. H. L., Lemaerts, F. M.: Is it possible to predict the clinical effects of neuroleptic drugs from animal data ? Part IV. Arzneimittel-Forsch. (Drug Res.) 17, 841–854 (1967)
Kirby, R. J., Bell, D. S., Preston, A. C.: The effects of methylamphetamine on stereotyped behaviour, activity, startle and orientating response. Psychopharmacologia (Berl.) 25, 41–48 (1972)
Norton, S.: Amphetamine as a model for hyperactivity in the rat. Physiol. Behav. 11, 181–186 (1973)
Quinton, R. M., Halliwell, G.: Effects of methyl DOPA and DOPA on the amphetamine excitatory response in reserpinised rats. Nature (Lond.) 200, 178–179 (1963)
Randrup, A., Munkvad, I.: On the relation of tryptaminergic and serotonergic mechanisms to amphetamine induced abnormal behaviour. Acta pharmacol. (Kbh.) 21, 272–282 (1964)
Randrup, A., Munkvad, I.: Special antagonism of amphetamine induced abnormal behaviour. Psychopharmacologia (Berl.) 7, 416–422 (1966)
Randrup, A., Munkvad, I.: Stereotyped activities produced in several animal species and in man. Psychopharmacologia (Berl.) 11, 300–310 (1967)
Randrup, A., Munkvad, I.: Behavioural stereotypies induced by pharmacological agents. Pharmakopsychiat. Neuro-Psychopharmak. 1, 18–26 (1968)
Randrup, A., Munkvad, I.: Pharmacological studies on the brain mechanisms underlying two forms of behavioural excitation: Stereotyped hyperactivity, and rage. Ann. N. Y. Acad. Sci. 157, 928–938 (1969)
Randrup, A., Munkvad, I.: Biochemical, anatomical and physiological investigations of stereotyped behaviour induced by amphetamines. In: Amphetamines and related compounds. E. Costa and S. Garratini, eds. New York: Raven Press 1970
Rotrosen, J., Wallach, M. B., Angrist, B., Gershon, S.: Antagonism of apomorphineinduced stereotypy and emesis in dogs by thioridazine, haloperidol and pimozide. Psychopharmacologia (Berl.) 26, 185–194 (1972)
Scheel-Krüger, J.: Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain. Europ. J. Pharmacol. 14, 47–59 (1971)
SchiØrring, E.: Amphetamine induced selective stimulation of certain behaviour items with concurrent inhibition of others in an open field test with rats. Behaviour 39, 1–17 (1971)
Siegel, S.: Nonparametric statistics for the behavioural sciences. New York-Toronto-London: McGraw-Hill 1956
Snyder, S. H.: Amphetamine psychosis: A ‘Model’ Schizophrenia Mediated by Catecholamines. Amer. J. Psychiat. 170, 61–67 (1973)
Southgate, P. J., Mayer, S. R., Boxali, E., Wilson, A. B.: Some 5-hydroxytryptamine like actions of fenfluramine: a comparison with (+) amphetamine and diethylpropion. J. Pharmac. Pharmacol. 23, 600–605 (1971)
Taylor, M., Goudie, A. J., Williams, A.: The effects of chronic fenfluramine administration on behaviour and body weight. Psychopharmacologia (Berl.) 31, 63–76 (1973)
Wallach, M. B., Gershon, S.: A neuropsychopharmacological comparison of d-amphetamine, l-dopa and cocaine. Neuropharmacology 10, 743–752 (1971)
Wallach, M. B., Gershon, S.: The induction and antagonism of central nervous system stimulant-induced stereotyped behaviour in the cat. Europ. J. Pharmacol. 18, 22–26 (1972)
Wray, S. R.: Possible catecholamine Mediation of levallorphan-induced behavioural disruption in rats. Psychopharmacologia (Berl.) 30, 251–262 (1973)
Yelnosky, J., Lawler, R. B.: A comparative study of the pharmacological action of amphetamine and fenfluramine. Arch. int. Pharmacodyn. 184, 374–383 (1970)
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The work reported here represents part of an M. Sc. thesis to be submitted to the Department of Psychology, University College of North Wales.
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Taylor, M., Goudie, A.J., Mortimore, S. et al. Comparison between behaviours elicited by high doses of amphetamine and fenfluramine: Implications for the concept of stereotypy. Psychopharmacologia 40, 249–258 (1974). https://doi.org/10.1007/BF00429419
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DOI: https://doi.org/10.1007/BF00429419