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Propranolol in the treatment of opiate dependence — a controlled study

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  • Human Pharmacology
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Abstract

Two doubleblind placebo controlled experiments designed to elucidate the alleged narcotic blocking effect of propranolol were performed. In the first experiment, propranolol 40 mg or 20 mg was given together with methadone during the acute withdrawal phase of opiate addiction. The second experiment assessed whether 10 mg of propranolol, given 2 hrs before 30 mg of morphine i.v., reduced the euphoric effects of the latter drug. In none of the experiments could narcotic blocking effects be detected. The group receiving 40 mg propranolol during detoxification exhibited the highest proportion of patients staying for the whole prescribed detoxification period.

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References

  • Aitken, R. C. B.: Measurement of feeling using visual analogue scales. Proc. roy. Soc. Med. 62, 989–996 (1969)

    Google Scholar 

  • Grosz, H. J.: Narcotic withdrawal symptoms in heroin users treated with propranolol. Lancet 1972 II, 564–566

    Google Scholar 

  • Grosz, H. J.: Effect of propranolol on active users of heroin. Lancet 1973 II, 612

    Google Scholar 

  • Gunne, L.-M., Holmstrand, J.: Clinical studies on methadone-morphine interaction. Proceedings, 9th International Congress of the Collegium Internationale Neuropsychopharmacologicum, Paris, July 7–12, 1974. Excerpta Medica (in press)

  • Hollister, L. E.: Propranolol as a possible treatment of opiate dependence. Abstracts from Symposium no 3 “Drug abuse: new models, new treatments” CINP Meeting, Paris, July 1974

  • Mulé, S. J.: Routine identification of drugs of abuse in human urine. J. Chromatogr. 55, 255–266 (1971)

    Google Scholar 

  • Siegel, S.: Nonparametric statistics. New York: McGraw-Hill Book 1956

    Google Scholar 

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Authors and Affiliations

  1. Psychiatric Research Center, Ulleråker Hospital, University of Uppsala, Uppsala

    Rolf G. Jacob, Jan Holmstrand, Jan H. Eriksson & Erik Änggård

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  1. Rolf G. Jacob
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  2. Jan Holmstrand
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  3. Jan H. Eriksson
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  4. Erik Änggård
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Jacob, R.G., Holmstrand, J., Eriksson, J.H. et al. Propranolol in the treatment of opiate dependence — a controlled study. Psychopharmacologia 41, 71–73 (1975). https://doi.org/10.1007/BF00421309

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  • DOI: https://doi.org/10.1007/BF00421309

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