Abstract
A series of three experiments examined the possible involvement of endogenous opioid peptides in the development of schedule-induced polydipsia in rats. Repeated pretraining treatment with 2 mg/kg naloxone impaired acquisition of schedule-induced polydipsia, whereas the same treatment injected after training increased drinking. This later effect was time dependent, since a 30-min delay in the injection of naloxone resulted in a disappearance of its effect. Post-training injections of 10 μg/kg β-endorphin or ACTH delayed the development of drinking. These findings are consistent with the hypothesis that endogenous opioid peptides modulate the development of schedule-induced polydipsia.
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Tazi, A., Dantzer, R., Mormede, P. et al. Effects of naloxone, β-endorphin and ACTH on acquisition of schedule-induced polydipsia. Psychopharmacology 85, 87–91 (1985). https://doi.org/10.1007/BF00427328
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DOI: https://doi.org/10.1007/BF00427328