Abstract
Serum corticosterone levels were determined following administration of the cholinergic agonist arecoline (4 mg/kg) to rats selectively bred for differences in cholinergic function. The Flinders Sensitive Line (FSL) of rats exhibited both greater suppression of behavioural activity and enhanced elevation fo serum corticosterone than the Flinders Resistant Line of rats. These enhanced responses to arecoline in the FSL rats parallel those reported in depressed humans, suggesting that these rats may provide a new animal model of affective disorders.
References
Janowsky DS, Risch SC, Parker D, Huey LY, Judd LL (1980) Increased vulnerability to cholinergic stimulation in affect disorder patients. Psychopharmacol Bull 16:29–31
Overstreet DH (1985) Selective breeding for increased cholinergic function: Development of a new animal model of depression. Biol Psychiatr (in press)
Overstreet DH, Russell RW (1982) Selective breeding for sensitivity to DFP: Effects of cholinergic agonists and antagonists. Psychopharmacology 78:150–154
Risch SC, Janowsky DS, Gillin JC (1983a) Muscarinic supersensitivity of anterior pituitary ACTH and beta endorphin release in major depressive illness. Peptides 4:789–792
Risch SC, Siever LJ, Gillin JC, Janowsky DS, Sitaram N, Weker J, Cohen RM, Murphy DL (1983b) Differential mood effects of arecoline in depressed patients and normal volunteers. Psychopharmacol Bull 19:696–698
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Overstreet, D.H., Booth, R.A., Dana, R. et al. Enhanced elevation of corticosterone following arecoline administration to rats selectively bred for increased cholinergic function. Psychopharmacologia 88, 129–130 (1986). https://doi.org/10.1007/BF00310528
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DOI: https://doi.org/10.1007/BF00310528