Zusammenfassung
Segmente der Arteria facialis des Rindes wurden unter einen Innendruck von 100 mm Hg gesetzt. Dieser wurde fortlaufend isometrisch registriert, während die Arterien nach der Übertropfmethode verschiedenen Kalium-Konzentrationen ausgesetzt wurden.
Kalium-Konzentrationen bis zu 35 mmol/l erniedrigen den Druck der Arteriensegmente. Die maximale Gefäßdilatation wurde bei 10 mmol/l erreicht. Weitere Steigerung der Kalium-Konzentration verminderte die Dilatation. Kalium-Konzentrationen über 50 mmol/l führen stets zur Gefäßconstriction.
Herabsetzung der Kalium-Konzentration steigert den Innendruck der Arterien. Der Druckanstieg war anhaltend (bis zu 60 min beobachtet).
Tetrodotoxin (8·10−7 g/ml) hatte keinen Einfluß auf die Kaliumwirkungen.
Die Befunde werden in Hinsicht auf eine mögliche Funktion des Kaliums bei der Regulation der Durchblutung — besonders am arbeitenden Muskel — erörtert.
Summary
Segments of bovine facial arteries were placed under a pressure of 100 mm Hg and the inside pressure was isometrically recorded. The arteries were rinsed from outside with various potassium solutions.
An increase in the potassium concentration decreases the pressure of the arteries up to a concentration of about 35 mmole/l. Maximum of dilatation was reached with 10 mmole/l potassium chloride. The vasodilatation was lessened by a further increase in the potassium concentration but was still present. Concentrations more than 50 mmole/l potassium chloride invariably lead to contracture.
Decrease in the potassium concentration increased the pressure of the arteries and this effect was maintained for a long period of time (observed up to 60 min).
Tetrodotoxin (8×10−7 g/ml) does not influence the potassium effects.
The results are discussed with regard to the role of potassium in the regulation of blood flow, especially during muscular activity.
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Dedicated to Professor H. Lullies on the occasion of his 70th birthday.
This investigation was supported by the “Deutsche Forschungsgemeinschaft”.
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Konold, P., Gebert, G. & Brecht, K. The effect of potassium on the tone of isolated arteries. Pflügers Archiv 301, 285–291 (1968). https://doi.org/10.1007/BF00362638
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DOI: https://doi.org/10.1007/BF00362638