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Isometric training of rats — Effects upon fast and slow muscle and modification by an anabolic hormone (Nandrolone Decanoate)

I. Female rats

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Summary

Some effects of isometric exercise were studied in fast rectus femoris muscle and slow soleus muscle of the female rat. Isometric twitch contraction time shortened by 20% in fast and prolonged by 20% in slow muscle. Maximum tetanic tension increased by 20% in the fast muscle. Changes in the enzyme activity pattern of energy supplying metabolism differed in the two muscles. The different responses may be explained by different topography and differences in fibre composition. There was an increase in creatine kinase, glycogen phosphorylase and triosephosphate dehydrogenase in rectus femoris muscle. The same enzymes were found to decrease slightly in soleus muscle. Treatment of the animals with Nandrolone Decanoate caused a higher performance of the trained animals. In the rectus femoris muscle hormone treatment alone caused similar increases in glycogenolytic and glycolytic enzymes as did training. Additionally, an increase of glycogen synthetase was induced by the hormone. These changes could not be increased by additional training. In soleus muscle hormone treatment alone caused a decrease in muscle strength. In hormone treated exercising animals the prolongation of isometric twitch contraction time was not found.

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Authors and Affiliations

  1. Fachbereich Biologie, Universität Konstanz, D-7750, Konstanz, Germany

    Gerhard Ulrich Exner, Hans W. Staudte & Dirk Pette

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  1. Gerhard Ulrich Exner
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  2. Hans W. Staudte
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  3. Dirk Pette
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Postdoctoral fellow of Deutsche Forschungsgemeinschaft. The investigation was supported by a grant of Deutscher Sportbund.

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Exner, G.U., Staudte, H.W. & Pette, D. Isometric training of rats — Effects upon fast and slow muscle and modification by an anabolic hormone (Nandrolone Decanoate). Pflugers Arch. 345, 1–14 (1973). https://doi.org/10.1007/BF00587057

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  • DOI: https://doi.org/10.1007/BF00587057

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