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Autoregulation of the glomerular filtration rate and the single-nephron glomerular filtration rate despite inhibition of tubuloglomerular feedback in rats chronically volume-expanded by deoxycorticosterone acetate

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Abstract

Tubuloglomerular feedback (TGF) function and autoregulation (renal blood flow RBF; glomerular filtration rate, GFR; single-nephron glomerular filtration rate, SNGFR) were examined in rats chronically treated with deoxycorticosterone acetate (DOCA) and given isotonic saline to drink. DOCA treatment depressed arterial plasma renin activity, expanded plasma volume by 25% and increased arterial blood pressure. Autoregulation of RBF and GFR was maintained in the DOCA animals above 90 mm Hg and 110 mm Hg respectively, whereby both GFR and RBF were lower than in controls. Micropuncture experiments demonstrated the absence of TGF in the DOCA animals. There was no difference between SNGFR values measured in the distal and proximal tubules, nor was there a significant response of SNGFR when loops of Henle were perfused with Ringer's solution at 20 nl/min. Loop perfusion in control rats with tubular fluid collected in DOCA rats elicited a normal TGF response, showing that TGF inhibition in the DOCA animals is due to changes in the function of the juxtaglomerular apparatus. In contrast to control rats, proximal SNGFR was perfectly autoregulated. These results suggest that TGF is not primarily responsible for autoregulation and that the vasodilatation normally resulting from acute TGF interruption is therefore compensated by some other mechanism such that RBF and GFR are lower than in controls.

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References

  1. Arendshorst WJ, Finn WF (1977) Renal hemodynamics in rats before and during inhibition of angiotensin II. Am J Physiol 233: F290-F297

    Google Scholar 

  2. Aukland K, Oien AH (1987) Renal autoregulation: models combining tubuloglomerular feedback and myogenic response. Am J Physiol 252: F768-F783

    Google Scholar 

  3. Baylis C (1978) Mechanism of the glucocorticoid-induced increase in glomerular filtration rate. Am J Physiol 234: F166-F170

    Google Scholar 

  4. Bergmeyer HU, Bernt E, Schmidt F, Stork H (1974) Inulin. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Verlag Chemie, Weinheim, pp 1196–1201

    Google Scholar 

  5. Chou CL, Marsh DJ (1986) Role of proximal tubule in pressure diuresis in the rat. Am J Physiol 251: F283-F298

    PubMed  Google Scholar 

  6. Davis JM, Häberle DA, Kawata T (1988) The control of glomerular filtration rate and renal blood flow in chronically volume expanded rats. J Physiol (Lond) 402: 473–495

    Google Scholar 

  7. Davis JM, Takabatake T, Häberle DA (1988) The influence of renal autoregulation on TGF control of glomerular filtration rate. In: Persson AEG, Boberg U (eds) The juxtaglomerular apparatus. Elsevier, Amsterdam, pp 393–406

    Google Scholar 

  8. Dev B, Drescher C, Schnermann J (1974) Resetting of tubuloglomerular feedback sensitivity by dietary salt intake. Pflügers Arch 346: 252–277

    Google Scholar 

  9. Douglas JG (1987) Corticoids decrease glomerular angiotensin receptors. Am J Physiol 252: F453-F457

    PubMed  Google Scholar 

  10. Fagard RH, Amery AK, Lijnen PJ (1978) Renal response to angiotensin II and 1-Sar-8-Ala-AII in sodium replete- and deplete dogs. Pflügers Arch 374: 199–204

    Google Scholar 

  11. Fitts DA, Yang OO, Corp ES, Simpson JB (1983) Sodium retention and salt appetite following desoxycorticosterone in hamsters. Am J Physiol 244: R78-R83

    Google Scholar 

  12. Fregly MJ, Rowland NE, Luttge WG (1985) Effect of chronic administration of deoxycorticosterone acetate on salt appetite of captopril treated rats. Endocrinology 116: 1391–1398

    PubMed  Google Scholar 

  13. Führ J, Kaczmarczyk J, Krüttgen CD (1955) Eine einfache colorimetrische Methode zur Inulinbestimmung für Nierenclearanceuntersuchungen bei Stoffwechselgesunden und Diabetikern. Klin Wochenschr 33: 729–730

    Google Scholar 

  14. Häberle DA (1988) Hemodynamic interactions between intrinsic blood flow control mechanisms in the rat kidney. Renal Physiol 11: 289–315

    Google Scholar 

  15. Häberle DA, Davis JM (1984) Resetting of tubuloglomerular feedback: evidence for a humoral factor in tubular fluid. Am J Physiol 246: F495-F500

    PubMed  Google Scholar 

  16. Hall JE, Guyton AC, Cowley AWJ (1977) Dissociation of renal blood flow and filtration rate autoregulation by renin depletion. Am J Physiol 232: F215-F221

    Google Scholar 

  17. Johnston PA, Bernard DB, Perrin NS, Arbeit L, Lieberthal W, Levinsky NG (1981) Control of rat renal vascular resistance during alterations in sodium balance. Circ Res 48: 728–733

    Google Scholar 

  18. Kaloyanides GJ, Ahrens RE, Shepherd JA, DiBona GF (1976) Inhibition of prostaglandin E2 secretion: failure to abolish autoregulation in the isolated dog kidney. Circ Res 38: 67–73

    Google Scholar 

  19. Kimbrough HM, Vaughan ED, Cavey RM, Ayers CR (1977) Effect of intrarenal angiotensin II blockade on renal function on conscious dogs. Circ Res 40: 174–178

    PubMed  Google Scholar 

  20. Medes G, Bellis CJ (1934) The effect of altering renal blood pressure on glomerular filtration. Am J Physiol 107: 227–229

    Google Scholar 

  21. Medes G, Herrick JF (1933) Blood flow to the kidney and creatinine clearance. Proc Soc Exp Biol Med 31: 116–119

    Google Scholar 

  22. Moore LC, Mason J (1986) Tubuloglomerular feedback control: effect of extracellular volume. Am J Physiol 250: F1024-F1032

    Google Scholar 

  23. Moore LC, Chnermann J, Yarimizu S (1979) Feedback mediation of SNGFR autoregulation in hydropenic and DOCA- and salt-loaded rats. Am J Physiol 237: F63-F74

    Google Scholar 

  24. Murray RD, Malvin RL (1976) Intrarenal renin and autoregulation of renal plasma flow and glomerular filtration rate. Am J Physiol 236: F559-F566

    Google Scholar 

  25. Navar LG, Bell PD, Burke TJ (1982). Role of a macula densa feedback mechanism as a mediator of renal autoregulation. Kidney Int 22 [Suppl 12]: S-157–S-164

    Google Scholar 

  26. Ploth DW, Rudulph J, LaGrange R, Navar LG (1979) Tubuloglomerular feedback and single nephron function after converting enzyme (SQ 20881) inhibition in the rat. J Clin Invest 64: 1325–1335

    PubMed  Google Scholar 

  27. Potkay S, Gilmore JP (1973) Autoregulation of glomerular filtration in renin depleted dogs. Proc Soc Exp Biol Med 143: 508

    Google Scholar 

  28. Rein H (1931) Vasomotorische Regulationen. Ergeb Physiol 31: 28–72

    Google Scholar 

  29. Renschler HE (1963) Die Anwendung enzymatischer Methoden zur Bestimmung von Inulin. Klin Wochenschr 41: 615–618

    PubMed  Google Scholar 

  30. Rosenthal JH, Pfeifle B, Michailov M, Pschorr J, Jacob ICM, Dahlheim H (1984) Investigations of components of the renin-angiotensin system in rat vascular tissue. Hypertension 6: 383–390

    Google Scholar 

  31. Schiffrin EL, Gutkowska J, Genest J (1984) Effect of angiotensin II and deoxycorticosterone infusion on vascular angiotensin II receptors in rats. Am J Physiol 246: H608-H614

    Google Scholar 

  32. Schnermann J, Briggs JP (1989) Interaction between loop of Henle flow and arterial pressure as determinants of glomerular pressure. Am J Physiol 256: F421-F429

    PubMed  Google Scholar 

  33. Schnermann J, Weber PC (1982) Reversal of indomethacin-induced inhibition of tubuloglomerular feedback by prostaglandin infusion. Prostaglandins 24: 351–361

    Article  Google Scholar 

  34. Schnermann J, Hermle, M, Schmidmeier E, Dahlheim H (1975) Impaired potency for feedback regulation of glomerular filtration rate in DOCA-escaped rats. Pflügers Arch 358: 325–338

    Google Scholar 

  35. Schnermann J, Schubert G, Hermle M, Herbst R, Stowe NT, Yarimizu S, Weber PC (1979) The effect of inhibition of prostaglandin synthesis on tubuloglomerular feedback in the rat kidney. Pflügers Arch 379: 269–286

    Google Scholar 

  36. Simpson FO, Ledingham JM, Paulin JM, Purves RD (1986) Body sodium in rats: response to DOCA, adrenalectomy, changes in salt intake, and a salt load. Am J Physiol 250: 551–558

    Google Scholar 

  37. Zambraski EJ, Ciccone CD (1987) Effects of aortic constriction and renal denervation in DOCA-hypertensive swine. Am J Physiol 253: F1223-F1231

    Google Scholar 

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Authors and Affiliations

  1. Physiologisches Institut der Universität München, Pettenkoferstrasse 12, D-8000, Munich 2, Germany

    D. A. Häberle, B. Königbauer, J. M. Davis, C. Mast, C. Metz & H. Dahlheim

  2. Tokyo Women's Medical College, Kidney Center, Kawada-cho 8-1, Shinjuku-Ku, Tokyo, Japan

    T. Kawata

Authors
  1. D. A. Häberle
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  2. B. Königbauer
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  3. J. M. Davis
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  4. T. Kawata
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  5. C. Mast
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  6. C. Metz
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  7. H. Dahlheim
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Häberle, D.A., Königbauer, B., Davis, J.M. et al. Autoregulation of the glomerular filtration rate and the single-nephron glomerular filtration rate despite inhibition of tubuloglomerular feedback in rats chronically volume-expanded by deoxycorticosterone acetate. Pflügers Arch. 416, 548–553 (1990). https://doi.org/10.1007/BF00382688

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  • DOI: https://doi.org/10.1007/BF00382688

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