Abstract
Using whole-cell patch-clamp techniques, we demonstrate, for the first time, that rat submandibular acinar cells contain a tetraethylammonium (TEA)-insensitive, Ca2+-activated K+ conductance which is not attributable to large conductance, voltage-sensitive, Ca2+-dependent K+ channels (maxi-K+ channels). Taken together with our recent K+ efflux and fluid secretion studies in intact rat submandibular gland, we postulate that the K+ conductance reported here may be involved in the basolateral K+ efflux pathway activated by cytosolic Ca2+ concentration during secretion by this gland.
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Ishikawa, T., Murakami, M. Tetraethylammonium-insetisitive, Ca2+-activated whole-cell K+ currents in rat submandibular acinar cells. Pflügers Arch. 429, 748–750 (1995). https://doi.org/10.1007/BF00373998
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DOI: https://doi.org/10.1007/BF00373998