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Methotrexate: Specific HPLC routine method involving column switching

Methotrexat: Eine spezifische HPLC-Routinemethode mit Säulenschaltung

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  • Chromatographic Methods
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Conclusion

The described HPLC method is rapid, easy to perform, and permits a reliable measurement of low MTX concentrations without time consuming extraction procedures. With respect to the possible cross-reaction of 7-OH MTX in FPIA, HPLC currently appears to be the method of choice for determination of late MTX serum levels after HDMTX infusions.

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References

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Authors and Affiliations

  1. Institut für Klinische Chemie I, Medizinische Hochschule Hannover, D-3000, Hannover 61, Federal Republic of Germany

    E. Raude, M. Oellerich & M. Wrenger

Authors
  1. E. Raude
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  2. M. Oellerich
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  3. M. Wrenger
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Raude, E., Oellerich, M. & Wrenger, M. Methotrexate: Specific HPLC routine method involving column switching. Z. Anal. Chem. 330, 384–385 (1988). https://doi.org/10.1007/BF00469304

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  • DOI: https://doi.org/10.1007/BF00469304

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