Summary
Following administration of trifluoperazine (a psychotropic drug of the phenothiazine group), the brains of rabbits were examined by electron microscopy, with special reference to the glycogen changes in the globus pallidus, and were compared with the normal materials. After seven days' intramuscular injections of trifluoperazine (10 mg/kg/day), abundant glycogen granules were accumulated in dendrites of pallidum. Those animals showed extrapyramidal symptoms throughout the period. The administration of the drug might inhibit either neural activity or the glycolytic metabolism in dendrites of the pallidum.
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Koizumi, J., Shiraishi, H. Glycogen accumulation in dendrites of the rabbit pallidum following trifluoperazine administration. Exp Brain Res 11, 387–391 (1970). https://doi.org/10.1007/BF00237912
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DOI: https://doi.org/10.1007/BF00237912