Summary
The experiment examines the role of the cerebral cortex in regulating responses to noxious stimulation by studying the effects of cortical ablations in cats on escape from electric shock applied to the foot pads. The latency of escape as a function of shock intensity was measured before and after bilateral ablations of various portions of the cat's somatosensory cerebral cortex. Ablations of the second somatosensory cerebral cortex significantly increased the escape response threshold. If the sulci bordering this region were included in the ablation, the threshold increase was greater and longer-lasting. Ablations of the primary somatosensory cortex increased latencies at most intensities of electric shock, but did not change the response thresholds. Ablations of both primary and second somatosensory cortex increased response thresholds and response latencies. None of these ablations altered the responses, however, if the cat had been overtrained for six to seven months prior to surgery. The results suggest that the second somatosensory region and the sulci bordering the second somatosensory region in the cat cerebral cortex are involved in responses to noxious stimulation.
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Bard, P.: Studies on the cerebral cortex. I. Localized control of placing and hopping reactions in the cat and their normal management by small cortical remnants. Arch. Neurol. Psychiat. (Chic.) 30, 40–74 (1933)
Benton, R.G., Mefferd, R.B., Jr.: The differentiation of escape and avoidance behavior in two thalamic areas in the cat. Brain Res. 6, 679–685 (1967)
Biemònd, A.: The conduction of pain above the level of the thalamus opticus. Arch. Neurol. Psychiat. (Chic.) 75, 231–244 (1956)
Brodal, A.: Neurological anatomy. London: Oxford Univ. Press 1969
Carreras, M., Andersson, S.A.: Functional properties of neurons of the anterior ectosylvian gyrus of the cat. J. Neurophysiol. 26, 100–126 (1963)
Casey, K.L.: Unit analysis of nociceptive mechanisms in the thalamus of the awake squirrel monkey. J. Neurophysiol. 29, 727–750 (1966)
Delgado, J.M.R.: Cerebral structures involved in transmission and elaboration of noxious stimulation. J. Neurophysiol. 18, 261–275 (1955)
Durinyan, R.A., Reshetnyak, V.K., Rabin, A.G.: Effects of stimulation of somatic cortical areas in unrestrained cats. Zh. vyssh. nerv. Deyat. Pavlova 22, 109–115 (1972)
Glassman, R.B.: Cutaneous discrimination and motor control following somatosensory cortical ablations. Physiol. Behav. 5, 1009–1019 (1970)
Glassman, R.B.: Discrimination of passively received kinesthetic stimuli following sensorimotor cortical ablations in cats. Physiol. Behav. 7, 239–243 (1971)
Graybiel, A.M.: Some thalamocortical projections of the pulvinar-posterior system of the thalamus in the cat. Brain Res. 22, 131–136 (1970)
Graybiel, A.M.: The thalamo-cortical projection of the so-called posterior nuclear group: a study with anterograde degeneration methods in the cat. Brain Res. 49, 229–244 (1973)
Hand, P.J., Morrison, A.R.: Thalamocortical projections from the ventrobasal complex to somatic sensory areas I and II. Exp. Neurol. 26, 291–308 (1970)
Hassler, R.: Die zentralen Systeme des Schmerzes. Acta neurochir. (Wien) 8, 353–423 (1960)
Hassler, R., Riechert, T.: Klinische und anatomische Befunde bei stereotaktischen Schmerzoperationen im Thalamus. Arch. Psychiat. Nervenkr. 200, 93–122 (1959)
Heath, C.J.: Distribution of axonal degeneration following lesions of the posterior group of thalamic nuclei in the cat. Brain Res. 21, 435–438 (1970)
Jones, E.G., Powell, T.P.S.: The cortical projection of the ventroposterior nucleus of the thalamus in the cat. Brain Res. 13, 298–318 (1969)
Kleist, K.: Gehirnpathologie. Leipzig: Barth 1934
Lende, R.A., Kirsch, W.M., Druckman, R.: Relief of facial pain after combined removal of precentral and postcentral cortex. J. Neurosurg. 34, 537–543 (1971)
Lewin, W., Phillips, C.G.: Observations on partial removal of the post-central gyrus for pain. J. Neurol. Neurosurg. Psychiat. 15, 143–147 (1952)
Marshall, J.: Sensory disturbances in cortical wounds with special reference to pain. J. Neurol. Neurosurg. Psychiat. 14, 187–204 (1951)
Meyer, D.R.: Some psychological determinants of sparing and loss following damage to the brain. In: logical and Biochemical Bases of Behavior pp. 173–192. Ed.by H.F. Harlow and C.N. Woolsey. Madison: Univ. of Wisconsin Press 1958
Morrison, A.R., Hand, P.J., O'Donoghue, J.: Contrasting projections from the posterior and ventrobasal thalamic nuclear complexes to the anterior ectosylvian gyrus of the cat. Brain Res. 21, 115–121 (1970)
Mountcastle, V.B.: Pain and temperature sensibilities. In: Medical Physiology, Vol. 2, 1424–1464. Ed. by V.B. Mountcastle. St. Louis: C.V. Mosby 1968
Mountcastle, V.B., Powell, T.P.S.: Neural mechanisms subserving cutaneous sensibility, with special reference to the role of afferent inhibition in sensory perception and discrimination. Bull. Johns Hopk. Hosp. 105, 201–232 (1959)
Neff, W.D.: Discriminative capacity of different divisions of the auditory system. In: Brain and Behavior, Vol. 1, pp. 205–262. Ed. by M.A.B. Brazier. Washington: Amer. Inst. Biol. Sci. 1961
Orbach, J., Fantz, R.L.: Differential effects of temporal neocortical resections on overtrained and non-overtrained visual habits in monkres. J. comp. physiol. Psychol. 51, 126–129 (1958)
Peele, T.L.: Acute and chronic parietal lobe ablations in monkeys. J. Neurophysiol. 7, 269–286 (1944)
Penfield, W., Rasmussen, T.: The cerebral cortex of man. New York: Macmillan 1950
Perl, E.R., Whitlock, D.G.: Somatic stimuli exciting spinothalamic projections to thalamio neurons in cat and monkey. Exp. Neurol. 3, 256–296 (1961)
Poggio, G.F., Mountcastle, V.B.: A study of the functional contributions of the lemniscal and spinothalamic systems to somatic sensibility. Bull. Johns Hopk. Hosp. 106, 266–316 (1960)
Ranson, S.W., Clark, S.L.: The anatomy of the nervous system. Philadelphia: W.B. Saunders 1959
Russell, W.R.: Transient disturbances following gunshot wounds of the head. Brain 68, 79–97 (1945)
Sinclair, D.: Cutaneous sensation. London: Oxford Univ. Press 1967
Thompson, R.R., Johnson, R.H., Hoopes, J.J.: Organization of auditory, somatic sensory, and visual projection to association fields of cerebral cortex in cat. J. Neurophysiol. 26, 343–364 (1963)
Truex, R.C., Carpenter, M.B.: Human neuroanatomy. Baltimore: Williams and Wilkins 1969
Van Hassel, H.J., Biedenbach, M.A., Brown, A.C.: Cortical potentials evoked by tooth pulp stimulation in rhesus monkeys. Arch, oral Biol. 17, 1059–1066 (1972)
Vierck, C.J., Jr., Hamilton, D.M., Thornby, J.I.: Pain reactivity of monkeys after lesions to the dorsal and lateral columns of the spinal cord. Exp. Brain Res. 13, 140–158 (1971)
Vyklický, L., Keller, O., Brožek, G., Butkhuzi, S.M.: Cortical potentials evoked by stimulation of tooth pulp afferents in the cat. Brain Res. 41, 211–213 (1972)
White, J.C., Sweet, W.H.: Pain and the neurosurgeon: a forty-year experience. Springfield: C.C. Thomas 1969
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Supported by PHS grant NS 02992. We thank Dr. D.R. Kenshalo for enlightening conversations and for critical comments on earlier drafts of the manuscript. We thank Dr. R. B. Masterton for permitting the loan and modification of the double-grill box and for advice during the early stages of training cats.
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Berkley, K.J., Parmer, R. Somatosensory cortical involvement in responses to noxious stimulation in the cat. Exp Brain Res 20, 363–374 (1974). https://doi.org/10.1007/BF00237381
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DOI: https://doi.org/10.1007/BF00237381