Summary
The hypotensive effect of acute sodium volume depletion, produced by chlorthalidone and a low sodium diet, was inversely related to the plasma renin concentration (PRC) in 13 hypertensive patients of varying aetiology (r=0.61; p<0.05); weight reduction induced by this therapy was not related to PRC (r=0.12; p>0.1). The angiotensin II antagonist 1-sar-8-ala-angiotensin II failed to reduce arterial pressure when the patients ingested 130 mEq sodium per day, but pressure fell when it was infused during sodium volume depletion, except when PRC remained low; the changes in pressure were related to the plasma renin level (r=0.78; p<0.005). The combined hypotensive response to acute sodium volume depletion and to angiotensin II blockade during sodium volume depletion was not related to PRC (r=0.15; p>0.1). The results demonstrate that acute sodium volume depletion caused similar weight loss in patients with high and low PRC values, and it would have had similar hypotensive effects but for angiotensin-induced vasoconstriction in the high renin patients. Since 1-sar-8-ala-angiotensin II also reduced arterial pressure in 6 patients during chronic diuretic therapy, angiotensin II must still induce vasoconstriction in these circumstances.
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Adlin, E.V., Marks, A.D., Channick, B.J.: Spironolactone and hydrochlorothiazide in essential hypertension. Arch. intern. Med.130, 855–858 (1972)
Carey, R.M., Douglas, J.G., Schweikert, J.R., Liddle, G.W.: The syndrome of suppressed plasma renin activity. Arch. intern. Med.130, 849–854 (1972)
Crane, M.G., Harris, J.J.: Effect of spironolactone in hypertensive patients. Amer. J. med. Sci.260, 311–330 (1970)
Fagard, R., Amery, A., Lijnen, P., Reybrouck, T., Billiet, L.: Haemodynamic effects of 1-sar-8-ala-angiotensin II in patients with renovascular hypertension. Progr. biochem. Pharmacol.12, 242–249 (1976a)
Fagard, R., Amery, A., De Plaen, J.F., Lijnen, P., Missotten, A.: Plasma renin concentration and the hypotensive effect of bendrofluazide and of atenolol. Clin. Sci. mol. Med.51, 215s-217s (1976b)
Editorial, When to measure renin. Lancet 1975I, 783–784
Laragh, J.H.: Vasoconstriction — Volume Analysis for Understanding and Treating Hypertension. The Use of Renin and Aldosterone Profiles. In: Hypertension Manual, pp. 823–849. Ed. Laragh, J.H.: New York: Med. Books 1973
Lijnen, P.J., Amery, A.K.P.C., Fagard, R.H.: Comparison between a biological and a radioimmunological assay of plasma renin concentration. FEBS Lett.61, 32–33 (1976)
Schalekamp, M.A., Beevers, D.G., Kolsters, G., Lebel, M., Fraser, R., Birkenhäger, W.H.: Body-fluid volume in low renin hypertension. Lancet 1974 II, 310–311
Skinner, S.L.: Improved assay methods for renin ‘concentration’ and ‘activity’ in human plasma. Circulat. Res.20, 391–402 (1967)
Spark, R.F., Melby, J.C.: Hypertension and low plasma renin activity: presumptive evidence for mineralocorticoid excess. Ann. intern. Med.75, 831–836 (1971)
Vaughan, E.D., Laragh, J.H., Gavras, I., Bühler, F.R., Gavras, H., Brunner, J.R., Baer, L.: Volume factor in low and normal renin essential hypertension: treatment with either spironolactone or chlorthalidone. Amer. J. Cardiol.32, 523–532 (1973)
Woods, J.W., Pittmann, A.W., Pulliam, C.C., Werk, E.E., Waidir, W., Allen, C.A.: Renin profiling in hypertension and its use in treatment with propranolol and chlorthalidone. New Engl. J. med.294, 1137–1143 (1976)
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Fagard, R., Amery, A., Lijnen, P. et al. Hypotensive effects of sodium volume depletion and 1-sar-8-ala-angiotensin II in relation to plasma renin in hypertensive patients. Eur J Clin Pharmacol 12, 1–5 (1977). https://doi.org/10.1007/BF00561398
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DOI: https://doi.org/10.1007/BF00561398