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Metabolism of phenazone in man after hydrocortisone administration

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Summary

The influence of a high plasma concentration of hydrocortisone on the metabolism of phenazone in humans has been studied. Two series of experiments were carried out, Group A to demonstrate any enzyme-inducing effect of hydrocortisone, and Group B to study the immediate effect of hydrocortisone on the metabolism of phenazone. 9 subjects (Group A) received a total 250–400 mg hydrocortisone i.m. twice daily for three days and the 24-hour elimination of phenazone was studied before and afterwards. In a further 5 subjects (Group B) the elimination of phenazone was examined during administration of hydrocortisone or placebo. The elimination rate and the apparent volume of distribution of phenazone remained unchanged under both experimental conditions.

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References

  1. von Bahr, C., Sjöqvist, F., Orrenius, S.: The inhibitory effect of hydrocortisone and testosteron on the plasma disappearance of nortriptylin in the dog and the perfused rat liver. Europ. J. Pharmacol.9, 106–110 (1970)

    Google Scholar 

  2. Baxter, J.D., Forsham, P.H.: Tissue effects of glucocorticoids. Amer. J. Med.53, 573–589 (1972)

    Google Scholar 

  3. Breckenridge, A., Burke, C.W., Davies, D.S., Orme, L.E.: Immediate decrease by hydrocortisone of the plasma half-life of antipyrine. Brit. J. Pharmacol.47, 434–436 (1973)

    Google Scholar 

  4. Cahill, G.F.: Action of adrenal cortical steroids on carbohydrate metabolism. In: The human adrenal cortex (ed. N.P. Christy) p. 205–239. New York: Harper and Row 1971

    Google Scholar 

  5. Castro, J.A., Greene, F.E., Gigon, P., Sasame, H., Gillette, J.R.: Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixed function oxygenase system of male rats which catalyses ethylmorphine metabolism. Biochem. Pharmacol.19, 2461–2467 (1970)

    Google Scholar 

  6. Clark, B., Thompson, J.W.: Analysis of the inhibition of pethidine N-demethylation by monoamine oxidase inhibitors and some other drugs with special reference to drug interactions in man. Brit. J. Pharmacol.44, 89–99 (1972)

    Google Scholar 

  7. Devereux, T.R., Fouts, J.R.: Effect of pregnancy or treatment with certain steroids on N,N-dimethylalanine demethylation and N-oxidation by rabbit liver or lung microsomes. Drug metab. Dispos.3, 254–258 (1975)

    Google Scholar 

  8. Elfström, J., Johansson, H., Lindgren, S.: Postoperative disappearance of phenazone from plasma in man. Europ. J. clin. Pharmacol.10, 63–68 (1976)

    Google Scholar 

  9. Flannagan, R.J., Richens, A.: The influence of elevated plasma hydrocortisone concentrations on antipyrine metabolism in man. Brit. J. clin. Pharmacol.1, 409–412 (1974)

    Google Scholar 

  10. Franksson, C., Gemzell, C.A., von Euler, U.S.: Cortical and medullary adrenal activity in surgical and allied conditions. J. clin. Endocrinol.14, 608–621 (1954)

    Google Scholar 

  11. Gelehrter, T.D.: Enzyme induction. New Engl. J. Med.294, 522–526, 589–595, 646–651 (1976)

    Google Scholar 

  12. Johnston, I.D.A.: The endocrine response to trauma. Adv. clin. Chem.15, 255–279 (1972)

    Google Scholar 

  13. Kehlet, H., Binder, Chr.: Alterations in distribution volume and biological half-life of cortisol during major surgery. J. clin. Endocrinol. Metab.36, 330–333 (1973)

    Google Scholar 

  14. Lindgren, S., Collste, P., Norlander, B., Sjöqvist, F.: Gas chromatographic assessment of the reproducibility of phenazone plasma half-lives in young healthy volunteers. Europ. J. clin. Pharmacol.7, 381–385 (1974)

    Google Scholar 

  15. de Moor, P., Osinski, P., Deckx, R., Steeno, O.: The specificity of fluorimetric corticoid determinations. Clin. Chim. Acta7, 475–480 (1962)

    Google Scholar 

  16. Plumpton, F.S., Besser, G.M., Cole, P.V.: Corticosteroid treatment and surgery. Anaesthesia24, 3–11 (1969)

    Google Scholar 

  17. Remmer, H.: Die Verstärkung der Abbaugeschwindigkeit von Evipan durch Glycocorticoide. Arch. exp. Path. Pharmacol.233, 184–191 (1958)

    Google Scholar 

  18. Tephly, T.R., Mannering, G.J.: Inhibition of drug metabolism by steroids. Mol. Pharmacol.4, 10–14 (1968)

    Google Scholar 

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Authors and Affiliations

  1. Department of Surgery and Department of Clinical Pharmacology, Regionsjukhuset, Linköping, Sweden

    J. Elfström & S. Lindgren

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  1. J. Elfström
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  2. S. Lindgren
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Elfström, J., Lindgren, S. Metabolism of phenazone in man after hydrocortisone administration. Eur J Clin Pharmacol 13, 69–72 (1978). https://doi.org/10.1007/BF00606685

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  • DOI: https://doi.org/10.1007/BF00606685

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