Summary
The effects of nalorphine 5 mg i. m., a partial opiate antagonist, on circulating levels of PRL, GH, TSH, LH, FSH and cortisol were studied in six healthy men. Nalorphine produced a prompt and sharp increase in serum PRL and a small, delayed rise in serum GH. Serum LH and cortisol decreased after drug administration and no change in serum FSH and TSH was observed. These findings are discussed and a possible site of action of nalorphine is suggested.
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Rolandi, E., Magnani, G., Sannia, A. et al. Hormonal changes induced by a partial opiate antagonist, nalorphine. Evaluation of PRL, GH, TSH, LH, FSH and cortisol secretion. Eur J Clin Pharmacol 21, 23–25 (1981). https://doi.org/10.1007/BF00609583
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DOI: https://doi.org/10.1007/BF00609583