Summary
The short-term efficacy of nitrendipine (N) as a first stage antihypertensive drug in black patients has been assessed and compared with acebutolol (A) in a double-blind study. Forty patients were randomized and after a 4 week run-in period on placebo, the active treatment was administered for 6 weeks starting with 20 mg N or 200 mg A once daily. The dose was increased up to 60 mg N or 600 mg A as needed. Nitrendipine appeared to be more efficient than acebutolol in reducing blood pressure and the N-induced fall in blood pressure was achieved after 2 weeks. After 2 and 6 weeks on N, the recumbent blood pressure was decreased by 13% and 12% for the systolic and by 14% and 11% for the diastolic pressure. The concurrent decreases in the A group averaged 4% and 5% for the systolic and 5% and 10% for the diastolic pressure after 2 and 6 weeks. Pulse rate and plasma renin activity in the N group were slightly increased and body weight was decreased at the end of the active treatment period.
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References
Andren L, Hansson L, Oro L, Kyman T (1982) Experience with nitrendipine, a new calcium antagonist in hypertension. J Cardiovasc Pharmacol 4 [Suppl 3]: S387-S391
Aoki K, Kondo S, Mochizuki A (1978) Antihypertensive effect of cardiovascular Ca2+-antagonist in hypertensive patients in the absence and presence of beta-adrenergic blockade. Am Heart J 96: 218–226
Brunner HR, Laragh JH, Baer L, Newton MA, Goodwin FT, Krakoff JR, Bard RH, Bühler FR (1972) Essential hypertension: Renin and aldosterone, heart attack and stroke. N Engl J Med 286: 441–449
Bühler FR, Laragh JH, Baer L, Vaughan ED Jr, Brunner HR (1972) Propranolol inhibition of renin secretion: A specific approach to diagnosis and treatment of renin dependent hypertensive diseases. N Engl J Med 287: 1209–1214
Bühler FR, Hulthen L, Kiowski W, Bolli P (1982) Greater antihypertensive efficacy of the calcium channel inhibitor verapamil in older and low renin patients. Clin Sci 63: 439s-442s
Channick BJ, Adlin EV, Marks AD (1969) Suppressed plasma renin activity in hypertension. Arch Intern Med 123: 131–140
Doyle AE (1983) Comparison of beta-adrenoceptor blockers and calcium antagonists in hypertension. Hypertension 5 [Suppl 2]: II 103-II 108
Drayer JIM, Weber MD, Longworth DL, Laragh JH (1978) The possible importance of aldosterone as well as renin in the long-term antihypertensive action of propranolol. Am J Med 64: 187–192
Ene MD, Williamson PJ, Roberts CJC, Waddell G (1983) Natriuretic effects of nifedipine and nitrendipine. Brit J Clin Pharmacol 17: 193 P
Esper RJ, Esper RC, Cassola D, Spitoso RA, Mosca H, Sami HH, Castro JM, Rohwedder RW (1984) Effectiveness of a new calcium antagonist, Bay-e-5009 nitrendipine, in the treatment of essential hypertension. In: Scriabine A, Vanoy S, Deck K (eds) Nitrendipine, Urban & Schwarzenberg, Baltimore-Munich, p 477
Fouad FM, Aboul-Khair M, Tarazi RC (1982) Heterogeneity of systemic hemodynamic response to a new calcium entry blocker, nitrendipine. J Cardiovasc Pharmacol 4 [Suppl 3]: S383-S386
Fyhrquist F, Puutula L (1978) Faster radioimmunoassay of angiotensin at 37°C. Clin Chem 24: 115–118
Harris L, Dargie HJ, Linch PG, Bulpitt CJ, Krikler DM (1982) Blood pressure and heart rate in patients with ischaemic heart disease receiving nifedipine and propranolol. Br Med J 284: 1148–1151
Helmer OM, Judson WE (1968) Metabolic studies on hypertensive patients with suppressed renin activity not due to hyperaldosteronism. Circulation 38: 965–976
Humphreys DG, Delvin DG (1968) Ineffectiveness of propranolol in hypertensive Jamaicans. Br Med J 2: 601–603
Lederballe Pedersen O, Mikkelsen E (1978) Acute and chronic effect of nifedipine in arterial hypertension. Eur J Clin Pharmacol 14: 375–381
Leonetti G, Pasotti C, Ferrari GP, Zanchetti A (1981) Double-blind comparison of antihypertensive effects of verapamil and propranolol. In: Zanchetti A, Krikler M (eds) Calcium antagonism in cardiovascular therapy. Excerpta Medica, Amsterdam, 260
Lewis GRJ, Morley KD, Lewis BM, Bones BJ (1978) The treatment of hypertension with verapamil. N Z Med J 84: 351–354
Lijnen P, Fagard R, Groeseneken K, M'Buyamba-Kabangu JR, Staessen J, Lissens W, Amery A (1984) Intracellular concentration and transmembrane fluxes of sodium and potassium in erythrocytes of normal male subjects. Effect of family history of hypertension and race. Neth J Med 27: 105–111
McLey RAB, Stallard TJ, Watson RDS, Littler WA (1983) The effect of nifedipine on arterial pressure and reflex cardiac control. Circulation 67: 1084–1090
Olivari MT, Bartolli C, Polese A, Fiorentini C, Moruzzi P, Guazzi MD (1979) Treatment of hypertension with nifedipine a calcium antagonist agent. Circulation 59: 1056–1062
Seedat YK (1980) Trial of atenolol and chlorthalidone for hypertension in black South Africans. Br Med J 281: 1241–1243
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M'Buyamba-Kabangu, J.R., Lepira, B., Fagard, R. et al. Relative potency of a beta-blocking and a calcium entry blocking agent as antihypertensive drugs in black patients. Eur J Clin Pharmacol 29, 523–527 (1986). https://doi.org/10.1007/BF00635887
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DOI: https://doi.org/10.1007/BF00635887