Summary
A study was performed to show whether debrisoquine phenotyping could be performed as an overnight procedure. Phenotyping of 33 normal volunteers was carried out during the day and night. A good correlation was observed between the day-and night-time metabolic ratios, although wide variation was observed in 3 subjects.
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References
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Lee, E.J.D. Diurnal effects on debrisoquine hydroxylation phenotyping. Eur J Clin Pharmacol 35, 441–442 (1988). https://doi.org/10.1007/BF00561381
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DOI: https://doi.org/10.1007/BF00561381