Summary
The potential interaction between fenoldopam, a DA1 selective agonist, and digoxin has been studied in 10 patients with heart failure (NYHA Class II or III) on chronic digoxin treatment. Plasma levels and urinary recovery of the glycoside were monitored for 24 h before and after 9 days of treatment with fenoldopam 100 mg tid.
Fenoldopam caused a small, non-significant decrease in the mean steady state plasma concentration and area under the plasma concentration curve of digoxin. As the clearance of digoxin was unchanged there does not appear to be an interaction between fenoldopam and digoxin at the level of the renal tubule.
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References
Allison NL, Dubb JW, Ziemniak JA, Alexander F, Stote RM (1987) The effect of fenoldopam, a dopaminergic agonist, on renal hemodynamics. Clin Pharmacol Ther 41: 282–287
Carey RM, Stote RM, Dubb JW, Townsend LH, Rose CE, Kaiser DL (1984) Selective peripheral dopamine-1-receptor stimulation with fenoldopam in human essential hypertension. J Clin Invest 74: 2198–2207
Cogan JJ, Humphreys MH, Carlson CJ, Benowitz NL, Repaport E (1981) Acute vasodilator therapy increases renal clearance of digoxin in patients with congestive heart failure. Circulation 64: 973–976
Gibson ThP, Quintainilla AP (1981) Effect of volume expansion and furosemide diuresis on the renal clearance of digoxin. J Pharmacol Exp Ther 219: 54–59
Hahn RA, Wardell JR Jr, Sarau HM, Ridley PT (1982) Characterization of the peripheral and central effects of SK&F 82526, a novel dopamine receptor agonist. J Pharmacol Exp Ther 223: 305–313
Halkin H, Sheiner LB, Peck CC, Melmon KH (1975) Determinants of the renal clearance of digoxin. Clin Pharmacol Ther 17: 385–394
Hilberman M, Maseda J, Stinson EB, Derby GC, Spencer RJ, Miller C, Oyer PE, Meyer BD (1984) The diuretic properties of dopamine in patients after open-heart operation. Anesthesiology 61: 489–494
Marcus FI (1985) Pharmacokinetic interactions between digoxin and other drugs. J Am Coll Cardiol 5: 82a-90a
Murphy MB, McCoy CE, Weber RR, Frederickson ED, Douglas FL, Goldberg LI (1987) Augmentation of renal blood flow and sodium excretion in hypertensive patients during blood pressure reduction by intravenous administration of the dopamine 1 agonist fenoldopam. Circulation 6: 1312–1318
Naafs MAB, van der Hoek C, Schopman W, Van Duin S, Koorevaar G, Silberbusch J (1983) Renal clearance of digoxin in man after sodium loading or furosemide treatment. Eur J Clin Pharmacol 25: 375–379
Pedersen KE, Dorph-Pedersen A, Hvidt S, Klitgaard NA, Nielsen-Kudsk F (1981) Digoxin-verapamil interaction. Clin Pharmacol Ther 30: 311–316
Schenck-Gustafsson K, Juhlin-Dannfelt A, Dahlquist R (1982) Renal function and digoxin clearance during quinidine therapy. Clin Physiol 2: 401–404
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Strocchi, E., Tartagni, F., Malini, P.L. et al. Interaction study of fenoldopam — digoxin in congestive heart failure. Eur J Clin Pharmacol 37, 395–397 (1989). https://doi.org/10.1007/BF00558507
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DOI: https://doi.org/10.1007/BF00558507