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Pharmacokinetics of diphemanil methylsulphate in healthy subjects

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Summary

The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax=2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered dose.

The results suggest low bioavailability, assuming that the drug is poorly metabolized.

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Authors and Affiliations

  1. Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France

    A. M. Vidal, E. Rey, G. Pons, J. Y. Pello, Ph. d'Athis & G. Olive

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  1. A. M. Vidal
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  2. E. Rey
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  3. G. Pons
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  4. J. Y. Pello
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  5. Ph. d'Athis
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  6. G. Olive
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Vidal, A.M., Rey, E., Pons, G. et al. Pharmacokinetics of diphemanil methylsulphate in healthy subjects. Eur J Clin Pharmacol 42, 689–691 (1992). https://doi.org/10.1007/BF00265939

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  • DOI: https://doi.org/10.1007/BF00265939

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