Skip to main content
SpringerLink
Log in

Stereoselective analysis of the disposition of tosufloxacin enantiomers in man

  • Short Communication
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

The pharmacokinetics of tosufloxacin enantiomers after oral administration of racemic tosufloxacin were examined in healthy volunteers. Only small differences were observed in time to peak concentration (2.6±0.3 [mean ± SEM] h for (+)-tosufloxacin vs 2.4±0.2 h for (−)-tosufloxacin), elimination half-life (3.61±0.24 h vs 3.49±0.23 h), and area under the curve (2.78±0.19 h·μg/ml vs 2.87±0.19 h·μg/ml); however, peak concentration (0.40±0.03 μg/ml vs 0.44±0.03 μg/ml), renal clearance (226±10 ml/min vs 202±10 ml/min), and urinary recovery (35.4±2.2% vs 32.4±1.9%) differed significantly between enantiomers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Fujimaki K, Noumi T, Hamana Y, Mitsuhashi S, Inoue M (1988) Antibacterial activity of T-3262. Chemotherapy 36 [Suppl 9]: 1–18

    Google Scholar 

  2. Rosen T, Chu DTW, Lico IM, Fernandes PB, Shen L, Borodkin S, Pernet AG (1988) Asymmetric synthesis and properties of the enantiomers of the antibacterial agent 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride. J Med Chem 31: 1586–1590

    Google Scholar 

  3. Yamaoka K, Tanigawara Y, Nakagawa T, Uno T (1981) A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobiodyn 4: 879–885

    Google Scholar 

  4. Yasuda T, Watanabe Y, Hayashi T, Kitayama R (1988) Serum protein binding of T-3262. Chemotherapy 36 [Suppl 9]: 143–148

    Google Scholar 

  5. Tai M, Sugimoto Y, Katayama Y, Maeda T (1988) Phase I study on T-3262 metabolites in serum, urine and feces. Chemotherapy 36 [Suppl 9]: 208–215

    Google Scholar 

  6. Hayakawa I, Atarashi S, Yokohama S, Imamura M, Sakano K, Furukawa M (1986) Synthesis and antibacterial activities of optically active ofloxacin. Antimicrob Agents Chemother 29: 163–164

    Google Scholar 

  7. Lehr KH, Damm P (1988) Quantification of the enantiomers of ofloxacin in biological fluids by high-performance liquid chromatography. J Chromatogr 425: 153–161

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacy, Kumamoto University Hospital, Honjo, Kumamoto, Japan

    R. Minami, N. Inotsume, C. Nakamura & M. Nakano

Authors
  1. R. Minami
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Inotsume
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Nakano
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Minami, R., Inotsume, N., Nakamura, C. et al. Stereoselective analysis of the disposition of tosufloxacin enantiomers in man. Eur J Clin Pharmacol 45, 489–491 (1993). https://doi.org/10.1007/BF00315523

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00315523

Key words

Search

Navigation