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Effect of food on the bioavailability of oxybutynin from a controlled release tablet

  • PHARMACOKINETICS AND DISPOSITION
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Abstract

Objective: The effect of food on the bioavailability of oxybutynin was assessed in a randomised cross-over study in 23 healthy volunteers. A single oral 10 mg dose of a controlled release oxybutynin tablet was administered after a high fat breakfast and to fasting subjects. The AUC, Cmax, tmax, t1/2 and MRT of oxybutynin and its active metabolite N-desethyloxybutynin were determined.

Results:

Breakfast did not change the AUC of oxybutynin but increased the AUC of N-desethyloxybutynin by about 20% . The Cmax of oxybutynin and N-desethyl oxybutynin were two-fold higher when the drug was administered after breakfast compared to the fasting state.

Conclusion:

Breakfast significantly reduced the MRT of oxybutynin and N-desethyloxybutynin.

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Authors and Affiliations

  1. Leiras Oy, Clinical Research, P.O. Box 325, FIN-00101 Helsinki, Finland, , , , , , FI

    E. Lukkari, P. Castrèn-Kortekangas, E. Löyttyniemi & K. Aranko

  2. Leiras Oy, Bioanalytical Laboratory, Turku, Finland, , , , , , FI

    A. Juhakoski

  3. Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland, , , , , , FI

    P. J. Neuvonen

Authors
  1. E. Lukkari
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  2. P. Castrèn-Kortekangas
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  3. A. Juhakoski
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  4. E. Löyttyniemi
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  5. K. Aranko
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  6. P. J. Neuvonen
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Additional information

Received: 6 October 1995/Accepted in revised form: 26 February 1996

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Lukkari, E., Castrèn-Kortekangas, P., Juhakoski, A. et al. Effect of food on the bioavailability of oxybutynin from a controlled release tablet. E J Clin Pharmacol 50, 221–223 (1996). https://doi.org/10.1007/s002280050096

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  • DOI: https://doi.org/10.1007/s002280050096

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