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Subacute reactions to intrathecal Amipaque (metrizamide), conray and dimer X: A structural and ultrastructural study

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Summary

Adult New Zealand rabbits were injected intrathecally with 200 or 300 mgI/ml of metrizamide, meglumine iocarmate or meglumine iothalamate. They were placed in the Trendelenburg position for 20 min and allowed to survive for 1, 2 or 3 weeks. Sacrifice was by intraarterial perfusion of aldehydes under anesthesia followed by preparation of brain and major venous sinuses for light and electron microscopy. Major findings were subpial edema and inflammatory reaction of superficial brain, leptomeninges, subarachnoid space and arachnoid granulations. They were most severe after iothalamate and milder after metrizamide. The severity decreased with time. It is of significance that severe reactions occurred after 300 mg I/ml concentration of metrizamide.

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Authors and Affiliations

  1. Department of Radiologyand William H. Harkness Research Building, Cornell University Medical College, New York, USA

    B. C. P. Lee, D. G. Gomez, D. G. Potts & A. M. Pavese

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  1. B. C. P. Lee
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  2. D. G. Gomez
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  3. D. G. Potts
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  4. A. M. Pavese
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Additional information

This work was supported by N.I.H. Grant RO1 NS 13844

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Lee, B.C.P., Gomez, D.G., Potts, D.G. et al. Subacute reactions to intrathecal Amipaque (metrizamide), conray and dimer X: A structural and ultrastructural study. Neuroradiology 20, 229–233 (1981). https://doi.org/10.1007/BF00342089

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  • DOI: https://doi.org/10.1007/BF00342089

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