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Serial imaging in MELAS

  • DIAGNOSTIC NEURORADIOLOGY
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Abstract

We report two patients with fatal mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Single-photon emission computed tomography (SPECT) with 123I-N-isopropyl-p-iodoamphetamine was more sensitive to the lesions than CT or MRI. SPECT showed focal hyperperfusion before or during the stroke and diffuse hypoperfusion of the brain, sparing the basal ganglia in the terminal stages. These findings support the theory that metabolic disturbance in the brain causes the “stroke” in MELAS.

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Authors and Affiliations

  1. Department of Pediatrics, Asahikawa Medical College, 4-5-3-11 Nishikagura, Asahikawa 078, Japan, , , , , , JP

    A. Miyamoto, J. Oki, S. Takahashi, J. Itoh, Y. Kusunoki & K. Cho

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  1. A. Miyamoto
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  2. J. Oki
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  3. S. Takahashi
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  4. J. Itoh
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  5. Y. Kusunoki
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  6. K. Cho
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Received: 22 April 1996 Accepted: 4 June 1996

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Miyamoto, A., Oki, J., Takahashi, S. et al. Serial imaging in MELAS. Neuroradiology 39, 427–430 (1997). https://doi.org/10.1007/s002340050438

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  • DOI: https://doi.org/10.1007/s002340050438

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