Summary
The early histological changes in bladder urothelium following transurethral cauterization were sequentially studied in female rats, mice, hamsters and guinea pigs. The changes differed markedly between species: papillary hyperplasia or papilloma in the rats and simple hyperplasia in the mice, hamsters and guinea pigs. The regenerative response to the fulgurative ulcer within a given species was similar to the early response previously observed by others following administration of known bladder carcinogens. This suggests that there may be a regulatory mechanism in the urothelium which is common to urothelial proliferations induced by both carcinogenic and non-carcinogenic stimulations, though differing between animal species.
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Abbreviations
- BBN:
-
N-buty-N-(4-hydroxybutyl)nitrosamine
- FANFT:
-
N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide
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Supported in part by Grant-in-Aid C-59570675 from the Japanese Ministry of Education, Science and Culture
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Akaza, H., Koseki, K. & Niijima, T. Species differences in regenerative hyperplasia of bladder urothelium after transurethral cauterization. Urol. Res. 14, 223–225 (1986). https://doi.org/10.1007/BF00441118
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DOI: https://doi.org/10.1007/BF00441118