Summary
Forty patients undergoing prostatectomy for benign prostatic hypertrophy were included in a double blind trial of epsilon aminocaproic acid, and the incidence of postoperative deep vein thrombosis determined, using the 125I-fibrinogen technique. There was no significant difference between the groups, the overall incidence of abnormal scans being 50 per cent, but of the patients undergoing enucleative prostatectomy 68 per cent developed significant scan findings compared with 33 per cent following transurethral surgery.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Atkins, P., Hawkins, L. A.: Detection of venous thrombosis in the legs. Lancet 1965 II, 1217
Andersson, L.: Studies on fibrinolysis in urinary tract disease and its treatment with epsilon aminocaproic acid. Acta chirurgica Scandinavica, Suppl. 301, 21 (1962)
Andersson, L.: Antifibrinolytic treatment with epsilon aminocaproic acid in connection with prostatectomy. Acta chirurgica Scandinavica 127, 552 (1964)
Becker, J., Borgstrom, S., Saltzman, G. F.: Occurrence and cause of thrombosis following prostatectomy — a phlebographic investigation. Acta radiologica 10, 513 (1970)
Flanc, C., Kakkar, V. V., Clarke, M. B.: Postoperative deep-vein thrombosis-effect of intensive prophylaxis. Lancet, 1969 I, 477
Gordon-Smith, I. G., Hickman, J. A., El Masri, S. H.: The effect of the fibrinolytic inhibitor epsilon aminocaproic acid on the incidence of deep vein thrombosis after prostatectomy. British Journal of Surgery 59, 522 (1972)
Kakkar, V. V., Nicolaides, A. N., Renney, J. T. G., Friend, J. R., Clarke, M. B.: 125I-labelled fibrinogen test adapted for routine screening for deep vein thrombosis. Lancet 1970 I, 540
Lawrence, A. C. K., Ward-McQuaid, J. N., and Holdom, G. L.: The effect of epsilon aminocaproic acid on the blood loss after retropubic prostatectomy. British Journal of Urology 38, 308 (1966)
Mayo, M. E., Halil, T., Browse, N. L.: The incidence of deep vein thrombosis after prostatectomy. British Journal of Urology 43, 738 (1971)
McNicol, G. P., Douglas, A. S.: In: Recent Advances in Clinical Pathology, ed. S. C. Dyke, p. 187. London: Churchill 1964
McNicol, G. P., Fletcher, A. P., Alkjaersig, N., Sherry, S.: Impairment of hemostasis in the urinary tract. The role of urokinase. Journal of Laboratory and Clinical Medicine 58, 34 (1961)
Nicolaides, A. N., Field, E. S., Kakkar, V. V., Yates-Bell, A. J., Taylor, S., Clarke, M. B.: Prostatectomy and deep vein thrombosis. British Journal of Surgery 59, 487 (1972)
Sack, E., Spaet, T. H., Gentile, R. I., Hudson, P. B.: Reduction of postprostatectomy bleeding by epsilon aminocaproic acid. New England Journal of Medicine 266, 541 (1962)
Vinnicombe, J., Shuttleworth, K. E. D.: Aminocaproic acid in the control of haemorrhage after prostatectomy. A controlled trial. Lancet 1966 II, 230
Vinnicombe, J., Shuttleworth, K. E. D.: Aminocaproic acid in the control of haemorrhage after prostatectomy. Safety of aminocaproic acid—a Controlled Trial. Lancet 1966 II, 232
Wood, E. H., Prentice, C. R. M., McNicol, G. P.: Association of fibrinogen fibrin-related antigen (F. R. antigen) with post-operative deep vein thrombosis and systemic complications. Lancet 1972 I, 166
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sinclair, J., Forbes, C.D., Prentice, C.R.M. et al. The incidence of deep vein thrombosis in prostatectomised patients following the administration of the fibrinolytic inhibitor, aminocaproic acid (EACA). Urol. Res. 4, 129–131 (1976). https://doi.org/10.1007/BF00257169
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00257169