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Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing Sarcoma of bone

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Abstract

Roentgenographic review of the first 210 cases of Ewing sarcoma (ES) in the Intergroup Ewing Sarcoma study revealed that 37.6% of cases had evidence of diffusely increased intraosseous density or diffuse sclerosis (DS). In these cases the sclerosis was usually mixed with various patterns of lysis and/or combined with a periosteal reaction. A radiograph blinded histologic review of selected biopsies showed an 83% incidence of dead bone compared to 23% in those without DS. Ten percent of the cases with DS had appositional new bone formation on dead bone whereas none of the cases without DS showed such reactions. Pathologic explanation of the roentgenographically identified diffuse sclerosis in ES has not been previously well documented in the medical literature.

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Author notes

  1. S. K. Shirley M.D.

    Present address: Department of Laboratories, Edward W. Sparrow Hospital Association, Lansing, Michigan

Authors and Affiliations

  1. Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA

    S. K. Shirley M.D. & J. M. Kissane M.D.

  2. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

    L. A. Gilula M.D.

  3. Department of Biomathematics, The University of Texas Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, Texas, USA

    M. A. Foulkes Ph.D.

  4. Division of Surgical, Department of Pathology, University of North Carolina at Chapel Hill, USA

    G. P. Siegal M.D., Ph.D. (G.P. Siegal is a Junior Faculty Clinical Fellow of the American Cancer Society (JFCF-739) & F. B. Askin M.D.

  5. Division of Oncologic Pathology, Department of Pathology, University of North Carolina at Chapel Hill, USA

    G. P. Siegal M.D., Ph.D. (G.P. Siegal is a Junior Faculty Clinical Fellow of the American Cancer Society (JFCF-739) & F. B. Askin M.D.

Authors
  1. S. K. Shirley M.D.
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  2. L. A. Gilula M.D.
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  3. G. P. Siegal M.D., Ph.D.
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  4. M. A. Foulkes Ph.D.
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  5. J. M. Kissane M.D.
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  6. F. B. Askin M.D.
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Additional information

For the Intergroup Ewing Sarcoma Study. The IESS Committee consists of Mark Nesbit, M.D.; Omer Burgert, Jr., M.D.; Ayten Cangir, M.D.; Teresa Vietti, M.D.; Douglas Pritchard, M.D.; John T. Makley, M.D.; James Neff, M.D.; Louis A. Gilula, M.D.; John M. Kissane, M.D.; Frederic B. Askin, M.D.; John Manning, M.D.; Edmund Gehan, Ph.D.; Mary Foulkes, Ph.D.; Melvin Tefft, M.D.; Carlos Perez, M.D.; Patrick Thomas, M.D.; Richard Evans, M.D.; Richard Ungerleider, M.D.; Will Hanson, Ph.D.; Stephen Condit; and Janice Schoppe

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Shirley, S.K., Gilula, L.A., Siegal, G.P. et al. Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing Sarcoma of bone. Skeletal Radiol 12, 69–78 (1984). https://doi.org/10.1007/BF00360810

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