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Osteopetrosis: An interpretation of its pathogenesis

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Abstract

Two children with osteopetrosis were studied radiographically and histologically. It is concluded that the histopathologic finding of excessive retentions of chondro-osseous tissue and failure of remodeling of bones is the result of retarded osteocytic osteolysis and osteocytic chondrolysis.

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References

  1. Bélanger LF (1968) Osteocytic osteolysis in pathological material. Cornell Vet 58:Suppl 1, 115

    Google Scholar 

  2. Bélanger LF (1969) Osteocytic osteolysis. Calcif Tissue Int 4:1

    Google Scholar 

  3. Bélanger LF, Rasmussen H (1968) Inhibition of osteocytic osteolysis by calcitonin and some anti-growth factors. In: Talmage RV, Belanger LF (eds) Parathyroid hormone and thyrocalcitonin (calcitonin). Excerpta Medica Foundation, Amsterdam Holland, p 156

    Google Scholar 

  4. Bélanger LF, Robichon J, Migicovsky BB, Copp DH, Vincent J (1966) Resorption without osteoclasts (osteolysis). In: Sognnaes FR (ed) Mechanisms of hard tissue destruction. Am Assoc Adv Sci, Washington, p 531

    Google Scholar 

  5. Bélanger LF, Semba R, Tolnai S, Copp DH, Krook L, Gries C (1966) The two faces of resorption Fleisch H, Blackwood HJJ, Owen M (eds) Third European Symposium on Calcified Tissues. Excerpta Medica Foundation, Amsterdam, p 1

    Google Scholar 

  6. Bélanger LF, Jarry L, Uhthoff HK (1968) Osteocystic osteolysis in Paget's disease. Rev Can Biol 27:37

    Google Scholar 

  7. Bélanger LF, Diamond MT, Copp DH (1973) Histological observations on bone and cartilage of growing turtles treated with calcitonin. Gen Comp Endocrinol 20:297

    Google Scholar 

  8. Brown WR, Krook L, Pond WG (1966) Atrophic rhinitis in swine. Cornell Vet 56:Suppl 1:1

    Google Scholar 

  9. Chineme CN, Krook L, Pond WG (1976) Bone pathology in hypervitaminosis D. An experimental study in young pigs. Cornell Vet 66:387

    Google Scholar 

  10. Coccia PF, Krivit W, Cervenka J, Clawson C, Kersey JH, Kim TH, Nesbit ME, Ramsay NKC, Warkentin PI, Teitelbaum SL, Kahn AJ, Brown DM (1980) Successful bone-marrow transplantation for infantile malignant osteopetrosis. N Engl J Med 302:701

    Google Scholar 

  11. Graham CB, Rudhe R, Eklöf P (1973) Osteopetrosis. Progr Pediat Radiol Intrinsic Diseases of Bones. 4:375

    Google Scholar 

  12. Haschek WM, Krook L, Kallfelz FA, Pond WG (1978) Vitamin D toxicity. Initial site and mode of action. Cornell Vet 68:324

    Google Scholar 

  13. Hedhammar A, Wu FM, Krook L, Schryver HF, Lahunta A de, Whalen JP, Kallfelz FA, Nunez EA, Hintz HF, Sheffy BE, Ryan GD (1974) Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs. Cornell Vet 64:Suppl 1, 1

    Google Scholar 

  14. Hsu FS, Krook L, Shively JN, Duncan JR, Pond WG (1973) Lead inclusion bodies in osteoclasts. Science 181:447

    Google Scholar 

  15. Hsu F, Krook L, Pond WG, Duncan JR (1975) Interactions of dietary calcium with toxic levels of lead and zinc in pigs. J Nutr 105:112

    Google Scholar 

  16. Krook L, Wasserman RH, McEntee K, Brokken TD, Teigland MB (1975) Cestrum diurnum poisoning in Florida cattle. Cornell Vet 65:557

    Google Scholar 

  17. Krook L, Wasserman RH, Shively JN, Tashjian AH Jr, Brokken TD, Morton JF (1975) Hypercalcemia nad calcinosis in Florida horses: Implication of the shrub, Cestrum diurnum, as the causative agent. Cornell Vet. 65:26

    Google Scholar 

  18. Marks SC Jr (1969) The parafollicular cells of the thyroid gland as the source of an osteoblast-stimulating factor. Evidence from experimentally osteopetrotic mice. J Bone Joint Surg 51:875

    Google Scholar 

  19. Marks SC Jr, Walker DG (1969) The role of the parafollicular cell of the thyroid gland in the pathogenesis of congenital osteopetrosis in mice. Am J Anat 126:299

    Google Scholar 

  20. Nunez EA, Hedhammer A, Wu FM, Whalen JP, Krook L (1974) Ultrastructure of the parafollicular (C) cells and the parathyroid cells in growing dogs on a high calcium diet. Lab Invest 31:96

    Google Scholar 

  21. Nunez EA, Horwith M, Krook L, Whalen JP (1979) An electron microscopic investigation of human familial bone dysplasia. Inhibition of osteocytic osteolysis and induction of osteocytic formation of elastic fibers following calcitonin treatment. Am J Pathol 94:1–18

    Google Scholar 

  22. Santos MN, Nunes VA, Nunes IJ, Barros SS de, Wasserman RH, Krook L (1976) Solanum malacoxylon toxicity: Inhibition of bone resorption. Cornell Vet 66:565–588

    Google Scholar 

  23. Walker DG (1966) Counteraction to parathyroid therapy in osteopetrotic mice as revealed in the plasma calcium level and ability to incorporate 3H-proline into bone. Endocrinology 79:836

    Google Scholar 

  24. Walker DG (1972) Congenital osteopetrosis in mice cured by parabiotic union with normal siblings. Endocrinology 91:916

    Google Scholar 

  25. Whalen JP, O'Donohue N, Krook L, Nunez EA (1973) Pathogenesis of abnormal remodeling of bones: Effects of yellow phosphorus in the growing rat. Anat Rec 177:15

    Google Scholar 

  26. Whalen JP, Krook L, MacIntyre I, Nunez EA (1975) Calcitonin, parathyroidectomy and modelling of bones in the growing rat. J Endocrinol 66:207

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York

    Lennart Krook D.V.M., Ph.D.

  2. Department of Radiology, The New York Hospital-Cornell Medical Center, New York, New York, USA

    Joseph P. Whalen M.D.

  3. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland

    Howard D. Dorfman M.D.

  4. Department of Radiology, Hospital for Joint Diseases Orthopaedic Institute, New York, New York, USA

    Alex Norman M.D.

  5. Department of Anatomy, College of Physicians and Surgeons, Columbia University, New York, New York, USA

    Eladio A. Nunez Ph.D.

Authors
  1. Lennart Krook D.V.M., Ph.D.
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  2. Joseph P. Whalen M.D.
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  3. Howard D. Dorfman M.D.
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  4. Alex Norman M.D.
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  5. Eladio A. Nunez Ph.D.
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Krook, L., Whalen, J.P., Dorfman, H.D. et al. Osteopetrosis: An interpretation of its pathogenesis. Skeletal Radiol 7, 185–189 (1981). https://doi.org/10.1007/BF00361862

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