Abstract
Malignant melanoma is one of the most common primary intraocular neoplasms. Recently, 99mTc radiolabelled (Fab')2 fragments of monoclonal antibody 225.28S raised against cutaneous melanomas have been used for imaging uveal melanomas. We report here a case where uptake of radiolabelled antibody was observed in a choroidal melanoma of the right eye and a benign choroidal naevus of the left.
Similar content being viewed by others
References
Bomanji J, Hungerford JL, Solanki K, Granowska M, Britton KE (1987) Radioimmunoscintigraphy of ocular melanoma with 99mTc labelled cutaneous melanoma antibody fragments. Br J Ophthalmol 71:651–658
Bomanji J, Garner A, Prasad J, Albert DM, Hungerford JL, Granowska M, Britton KE (1987a) Characterization of ocular melanoma with cutaneous melanoma antibodies. Br J Ophthalmol 71:647–650
Dijk RA van (1978) The 32P test and other methods in the diagnosis of intraocular tumours. Docum Ophthalmol 46:1–132
Ganley JP, Comstock GW (1973) Benign nevi and malignant melanomas of the choroid. Am J Ophthalmol 76:19–25
Hagler WS, Jarrett WH, Killian JH (1977) The use of 32P test in the management of malignant melanoma of the choroid: a five year follow-up study. Trans Am Acad Opthalmol 83:49–60
Hungerford JL (1985) Current management of choroidal malignant melanoma. Br J Hosp Med 34:287–293
Shammas HF, Burton TC, Weingeist TA (1977) False-positive results with radioactive phosphorous test. Arch of Ophthalmol 95:2190–2192
Shields JA (1978) Accuracy and limitations of the 32P test in the diagnosis of ocular tumour: an analysis of 500 cases. Ophthalmology 85:950–966
Wilson BS, Imai K, Natali PG, Ferrone S (1981) Distribution and molecular characterisation of a cell surface and a cytoplasmic antigen detectable in human melanoma cells with monoclonal antibodies. Int J Cancer 28:293–300
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bomanji, J., Hungerford, J.L., Granowska, M. et al. Uptake of 99mTc labelled (Fab')2 fragments of monoclonal antibody 225.28S by a benign ocular naevus. Eur J Nucl Med 14, 165–166 (1988). https://doi.org/10.1007/BF00293543
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00293543