Abstract
Sequential changes in the regional distribution of technetium 99m Teboroxime (SQ30217) were evaluated in nine dogs with graded coronary artery stenosis, occlusion and reperfusion of either the left anterior descending or left circumflex arteries.99mTc-Teboroxime accumulation recorded by planar imaging was compared with directly measured coronary blood flow (Doppler) and regional myocardial perfusion (microspheres). Serial images were recorded beginning at the time of injection and continuing for the next 18 min. The data were summed from minutes 2–3, 3–6, 4–8 and 9–18 after injection for comparison with the other parameters. Myocardial clearance of Teboroxime was analysed at each level of blood flow. There was a linear relationship between the Teboroxime activity ratio (abnormal/normal) and coronary blood flow (r=0.96) and regional myocardial perfusion (r = 0.99). Zones of diminished perfusion were least apparent in the summed images recorded during minutes 2–3. In later images, the lesions were well visualized. The myocardial clearance half-times at 100%, 75% and 50% flow were not significantly different, while clearance half-time at total occlusion was significantly (P < 0.01) faster. In the 3–6, 4–8 and 9–18 minutes summed images, the Teboroxime activity ratio increased significantly (P < 0.01) after reperfusion compared with total occlusion.
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Chesebro JH, Knattlerud G, Roberts R, Borer J, Cohen LS, Dalen J, Dodge HT, Francis CK, Hollis D, Ludbrook P (1987) Thrombolysis in myocardial infarction (TIMI) trial, phase 1: a comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Circulation 76:142–154
Coleman RE, Maturi M, Nunn AD, Eckelman WC, Juri PN, Cobb FR (1986) Imaging of myocardial perfusion with Tc-99m-SQ30217: dog and human studies. J Nucl Med 27:893–894 (abstr)
Coleman RE, Maturi M, Nunn AD, Eckelman WC, Cobb FR (1987) Myocardial perfusion: comparison of SQ30217, thallium-201 and microspheres in dogs. J Nucl Med 28:1080 (abstr)
Gold HK, Leimbach RC, Garabedian HD, Yasuda T, Johns J, Grossbard EB, Palascios I, Collen D (1986) Acute coronary reocclusion after thrombolysis with recombinant human tissue-type plasminogen activator: prevention by a maintenance infusion. Circulation 73:347–352
Harrison DG, Ferguson DW, Collins SM, Skorton DJ, Erickson EE, Kioschos JM, Marcus ML, White CW (1984) Rethrombosis after reperfusion with streptokinase: importance of geometry of residual lesion. Circulation 69:991–999
Johnson LL, Seldin DW, Muschel M, Smith K, Blood DK, Cannon PJ (1987) Rest and exercise myocardial perfusion scans and clearance rates of SQ30217, a new technetium-99m perfusion imaging agent. J Am Coll Card [2 Suppl A]9:138A (abstr)
Leppo JA, Meerdink DJ (1990) Comparative myocardial extraction of two technetium-labeled BATO derivatives (SQ30217, SQ32014) and thallium. J Nucl Med 31:67–74
McKusick KA, Holman BL, Jones AG, Davison A, Rigo P, Vosberg AH, Moretti J (1986) Comparison of three Tc-99m isonitriles for detection of ischemic heart disease in humans. J Nucl ] Med 27:878 (abstr)
Meerdink D, Moring A, Leppo J (1987) Comparative myocardial transport of technetium-labeled SQ30217 (CARDIOTEC) and thallium-201. J Am Coll Card [2 Suppl A]9:137A (abstr)
Narra RK, Feld T, Wedeking P, Matyas J, Nunn AD, Coleman RE (1986) SQ30217, a technetium-99m labeled myocardial imaging agint which shows no interspecies differences in uptake. J Nucl Med 27:1051–1052 (abstr)
Narra RK, Nunn AD, Kuczynski BL, Feld T, Wedeking P, Eckelman WC (1989) A neutral technetium-99m complex for myocardial imaging. J Nucl Med 30:1830–1837
Nunn AD, Treher EN, Feld T (1986) Boronic acid adducts of technetium oxime complexes. A new class of neutral complexes with myocardial imaging capabilities. J Nucl Med 27:893 (abstr)
Okada RD, Glover D, Gaffney T, Williams S (1988) Myocardial kinetics of technetium-99m-hexakis-2-methylpropyl-isonitrile. Circulation 77:491–498
Seldin DW, Johnson LL, Blood DK, Muschel MJ, Smith KF, Wall RM, Cannon PJ (1989) Myocardial perfusion imaging with technetium-99m-SQ30217: comparison with thallium and coronary anatomy. J Nucl Med 30:312–319
Stewart RE, Schwaiger M, Hutchins GD, Chiao PC, Gallagher KP, Nguyen N, Petry NA, Rogers WL (1990) Myocardial clearance kinetics of technetium-99m-SQ30217: a marker of regional myocardial flow. J Nucl Med 31:1183–1190
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Pieri, P., Yasuda, T., Fischman, A.J. et al. Myocardial accumulation and clearance of technetium 99m Teboroxime at 100%, 75%, 50% and zero coronary blood flow in dogs. Eur J Nucl Med 18, 725–731 (1991). https://doi.org/10.1007/BF00956713
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DOI: https://doi.org/10.1007/BF00956713