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The clinical reliability of 99mTc-polyphosphate skeletal scintigraphy in the early detection of bone metastases

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Abstract

A comparison between 99mTc-polyphosphate and pyrophosphate for the early detection of skeletal metastases demonstrated a significant difference between them. Of 71 lesions visualized by polyphosphate scintigrams only 54 were to be found on pyrophosphate scintigrams. The lesions not visualized by pyrophosphate were associated with bone with a high bone-marrow content. It has been suggested that polyphosphate should be the reagent of choice for the detection of skeletal malignancy. In a retrospective study of 118 patients the diagnostic reliability of positive polyphosphate scintigrams was found to be in excess of 90% in patients where skeletal associated pain was the only indication of metastasis.

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References

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Authors and Affiliations

  1. Department of Nuclear and Internal Medicine, Rotterdamsch Radio-Therapeutisch Instituut, Groene Hilledijk 301, Rotterdam-Z, The Netherlands

    P. H. Cox & R. E. Treurniet

  2. Academisch Ziekenhuis bij de Universiteit van Amsterdam “Wilhelmina Gasthuis”, Amsterdam, The Netherlands

    A. J. Belfer

  3. Gemeente Ziekenhuis Bergweg, Interne Afdeling, Rotterdam, The Netherlands

    D. J. van Dongen

  4. Academisch Ziekenhuis Rotterdam-Dijkzigt, afd. Röntgendiagnostiek, Rotterdam, The Netherlands

    R. Perlberger

Authors
  1. P. H. Cox
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  2. A. J. Belfer
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  3. D. J. van Dongen
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  4. R. Perlberger
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  5. R. E. Treurniet
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Cox, P.H., Belfer, A.J., van Dongen, D.J. et al. The clinical reliability of 99mTc-polyphosphate skeletal scintigraphy in the early detection of bone metastases. Eur J Nucl Med 2, 43–46 (1977). https://doi.org/10.1007/BF00448106

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  • DOI: https://doi.org/10.1007/BF00448106

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