Summary
During the clinical course of a secondary plasma cell leukemia the cellular protein synthesis and immunoglobulin synthesis were measured in a cell-free system prepared from peripheral plasma cells. After treatment with cyclophosphamide and a combination of cyclophosphamide with melphalan and vincristine no change in the activity of total protein synthesis was found. In contrast, a decrease of total protein synthesis could be observed after treatment with BCNU combined with cyclophosphamide and Ara-C. The relative amount of 10–15% Ig-synthesis remained unchanged under the different chemotherapeutic regimes. These findings suggest a primary effect of BCNU on cellular protein synthesis in myeloma cells similar to that reported in HeLa cell cultures.
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Literatur
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Unterstützt von der Deutschen Forschungsgemeinschaft Projekt Em 20/3
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Emmerich, B., Maurer, R., Schmidt, G. et al. Einfluß verschiedener Zytostatika auf die Proteinsynthese in leukämischen Plasmazellen. Blut 38, 155–159 (1979). https://doi.org/10.1007/BF01007959
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DOI: https://doi.org/10.1007/BF01007959