Summary
A patient with acute lymphoblastic leukemia (ALL) with cells containing two types of cytoplasmic inclusions is described. The inclusions appeared as glubular bodies containing electron dense material with homogenous structure and as crystalloid formations confined in organelles with structure similar to that of the surrounding mitochondria. In distinction to other reports, these structures were not related to the endoplasmic reticulum. The possibility that some of them represented altered mitochondria is discussed.
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Brunning RD, Parkin J, Dick F, Nesbit M (1974) Unusual inclusions occurring in the blasts of four patients with acute leukemia and Down's syndrome. Blood 44: 735–741
Cawley JC, Barker CR, Britchford RD, Smith JL (1973) Intracellular IgA immunoglobulin crystals in chronic lymphocytic leukaemia. Clin Exp Immunol 13: 407–416
Clark C, Rydell RE, Kaplan ME (1973) Frequent association of IgM with crystalline inclusions in chronic lymphatic leukemic lymphocytes. N Engl J Med 289: 113–117
Costello C, Catovsky D, O'Brien M (1981) Cytoplasmic inclusions in a case of prolymphocytic leukemia. Am J Clin Pathol 76: 499–501
Hurez D, Flandrin G, Preud'Homme JL, Seligman M (1972) Unreleased intracellular monoclonal macroglobulin in chronic lymphocytic leukaemia. Clin Exp Immunol 10: 223–234
Kjeldsberg CR, Bearman RM, Rappaport H (1980) Prolymphocytic leukemia. An ultrastructural study. Am J Clin Pathol 73: 150–159
Lagios MD, Friedlander LM, Wallerstein RO, Bohannon RA (1974) Atypical azurophilic crystals in chronic lymphocytic leukemia. Am J Clin Pathol 62: 342–349
McCann SR, Whelan A, Greally J (1978) Intracellular λ light chain inclusions in chronic lymphocytic leukaemia. Br J Haematol 38: 367–371
Mandel EM, Lewinski U, Gafter U, Weiss S, Freidin N, Djaldetti M (1977) The presence of hepatic intramitochondrial crystalline inclusions in routine liver biopsies. Am J Med Sci 274: 61–67
Mennemeyer R, Hammar SP, Cathey WJ (1974) Malignant lymphoma with intracytoplasmic IgM crystalline inclusions. N Engl J Med 291: 960–963
Nies KM, Marshall J, Oberlin MA, Halpern MS, Brown JC (1976) Chronic lymphocytic leukemia with gamma chain cytoplasmic inclusions. Am J Clin Pathol 65: 948–956
Stefani S, Chandra S, Schrek R, Tonaki H, Knospe WH (1977) Endoplasmic reticulum-associated structures in lymphocytes from patients with chronic lymphocytic leukemia. Blood 50: 125–139
Yanagihara ET, Maeim F, Gale RP, Austin G, Waisman J (1980) Acute lymphoblastic leukemia with giant intracytoplasmic inclusions. Am J Clin Pathol 74: 345–349
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Djaldetti, M., Perek, J. & Zahavi, I. Two types of intracytoplasmic inclusions in the cells of a patient with acute lymphoblastic leukemia. Blut 47, 13–19 (1983). https://doi.org/10.1007/BF00321046
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DOI: https://doi.org/10.1007/BF00321046