Skip to main content

Advertisement

Log in

Two types of intracytoplasmic inclusions in the cells of a patient with acute lymphoblastic leukemia

  • Original Articles
  • Published:
Blut Aims and scope Submit manuscript

Summary

A patient with acute lymphoblastic leukemia (ALL) with cells containing two types of cytoplasmic inclusions is described. The inclusions appeared as glubular bodies containing electron dense material with homogenous structure and as crystalloid formations confined in organelles with structure similar to that of the surrounding mitochondria. In distinction to other reports, these structures were not related to the endoplasmic reticulum. The possibility that some of them represented altered mitochondria is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Brunning RD, Parkin J, Dick F, Nesbit M (1974) Unusual inclusions occurring in the blasts of four patients with acute leukemia and Down's syndrome. Blood 44: 735–741

    Google Scholar 

  2. Cawley JC, Barker CR, Britchford RD, Smith JL (1973) Intracellular IgA immunoglobulin crystals in chronic lymphocytic leukaemia. Clin Exp Immunol 13: 407–416

    Google Scholar 

  3. Clark C, Rydell RE, Kaplan ME (1973) Frequent association of IgM with crystalline inclusions in chronic lymphatic leukemic lymphocytes. N Engl J Med 289: 113–117

    Google Scholar 

  4. Costello C, Catovsky D, O'Brien M (1981) Cytoplasmic inclusions in a case of prolymphocytic leukemia. Am J Clin Pathol 76: 499–501

    Google Scholar 

  5. Hurez D, Flandrin G, Preud'Homme JL, Seligman M (1972) Unreleased intracellular monoclonal macroglobulin in chronic lymphocytic leukaemia. Clin Exp Immunol 10: 223–234

    Google Scholar 

  6. Kjeldsberg CR, Bearman RM, Rappaport H (1980) Prolymphocytic leukemia. An ultrastructural study. Am J Clin Pathol 73: 150–159

    Google Scholar 

  7. Lagios MD, Friedlander LM, Wallerstein RO, Bohannon RA (1974) Atypical azurophilic crystals in chronic lymphocytic leukemia. Am J Clin Pathol 62: 342–349

    Google Scholar 

  8. McCann SR, Whelan A, Greally J (1978) Intracellular λ light chain inclusions in chronic lymphocytic leukaemia. Br J Haematol 38: 367–371

    Google Scholar 

  9. Mandel EM, Lewinski U, Gafter U, Weiss S, Freidin N, Djaldetti M (1977) The presence of hepatic intramitochondrial crystalline inclusions in routine liver biopsies. Am J Med Sci 274: 61–67

    Google Scholar 

  10. Mennemeyer R, Hammar SP, Cathey WJ (1974) Malignant lymphoma with intracytoplasmic IgM crystalline inclusions. N Engl J Med 291: 960–963

    Google Scholar 

  11. Nies KM, Marshall J, Oberlin MA, Halpern MS, Brown JC (1976) Chronic lymphocytic leukemia with gamma chain cytoplasmic inclusions. Am J Clin Pathol 65: 948–956

    Google Scholar 

  12. Stefani S, Chandra S, Schrek R, Tonaki H, Knospe WH (1977) Endoplasmic reticulum-associated structures in lymphocytes from patients with chronic lymphocytic leukemia. Blood 50: 125–139

    Google Scholar 

  13. Yanagihara ET, Maeim F, Gale RP, Austin G, Waisman J (1980) Acute lymphoblastic leukemia with giant intracytoplasmic inclusions. Am J Clin Pathol 74: 345–349

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Djaldetti, M., Perek, J. & Zahavi, I. Two types of intracytoplasmic inclusions in the cells of a patient with acute lymphoblastic leukemia. Blut 47, 13–19 (1983). https://doi.org/10.1007/BF00321046

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00321046

Key words

Navigation