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Frozen vs. nonfrozen bone marrow for autologous transplantation in lymphomas: A report from the Spanish GEL/TAMO Cooperative Group

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Summary

To investigate the impact of frozen and nonfrozen bone marrow on engraftment kinetics and disease outcome, 94 patients with non-Hodgkin's lymphoma (NHL) autografted with frozen marrow (F group) were retrospectively compared with 38 who received marrow stored at 4° C or 10° C (NF group). The major end points of this study were time to hematopoietic recovery and early toxicity; disease response, diseasefree survival (DFS), and relapse rate were also analyzed. Upon comparison of the NF and F groups, no significant differences were found in the period of time required to achieve a granulocyte count higher than 0.5×109/l (20 and 22 days, respectively,p=0.47) or a platelet count higher than 20×109/l (28 and 27 days, respectively,p=0.54). In addition, both groups behaved similarly in respect to toxic death (NF group 13%, F group 22%,p=0.36), response rate (complete remission rate 78% in both groups), DFS (NF group 48%, F group 49%,p=0.66), and relapse rate (NF group 30, F group 19%,p=0.37). This study confirms that nonfrozen bone marrow is useful to support patients with NHL treated with myeloablative therapies.

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Authors and Affiliations

  1. Hospital Marqués de Valdecilla, Santander

    E. Conde, A. Iriondo, C. Richard & J. Baro

  2. Hospital Clínic, Barcelona

    J. Sierra, C. Rozman & E. Montserrat

  3. Hospital Santa Creu i Sant Pau, Barcelona

    S. Brunet & A. Domingo

  4. Hospital Ramón y Cajal, Madrid

    J. Pérez de Oteiza & J. García-Conde

  5. Hospital Nuestra Señora de Aranzazu, San Sebastián

    J. Marín

  6. Hospital Clinico, Salamanca

    D. Caballero

  7. Hospital Reina Sofía, Córdoba

    F. Martínez

  8. Hospital de Jerez de la Frontera, Cádiz

    A. León

  9. Hospital Clínico, Valencia

    J. García-Conde & C. Solano

  10. Hospital Nuestra Señora del Pino, Las Palmas de Gran Canaria

    F. Hernández-Navarro

  11. Hospital Nuestra Señora de Covadonga, Oviedo

    D. Carrera

  12. Hospital Vall d'Hebrón, Barcelona

    J. Zuazu

  13. Clínica Universitaria de Navarra, Pamplona

    J. Rifón

  14. Hospital Clínico, Madrid

    J. Díaz-Mediavilla

Authors
  1. J. Sierra
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  2. E. Conde
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  3. A. Iriondo
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  4. S. Brunet
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  5. J. Marín
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  6. J. Pérez de Oteiza
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  7. D. Caballero
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  8. F. Martínez
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  9. A. León
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  10. J. García-Conde
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  11. F. Hernández-Navarro
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  12. A. Domingo
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  13. D. Carrera
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  14. J. C. Reverter
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  15. C. Richard
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  16. J. Zuazu
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  17. J. Baro
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  18. J. Rifón
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  19. C. Solano
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  20. J. Díaz-Mediavilla
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  21. C. Rozman
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  22. E. Montserrat
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Consortia

Spanish Cooperative Group GEL/TAMO

Additional information

The activities of the Spanish Cooperative Group for Bone Marrow Transplants in Lymphomas (GEL/TAMO) are kindly supported by a grant from AMGEN, S.A., Spain

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Sierra, J., Conde, E., Iriondo, A. et al. Frozen vs. nonfrozen bone marrow for autologous transplantation in lymphomas: A report from the Spanish GEL/TAMO Cooperative Group. Ann Hematol 67, 111–114 (1993). https://doi.org/10.1007/BF01701731

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  • DOI: https://doi.org/10.1007/BF01701731

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