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Clinical application of allogeneic peripheral blood stem cells transplantation

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Abstract

Recombinant human granulocyte colonystimulating factor (rhG-CSF)-mobilized peripheral blood stem cells (PBSC) are now widely used for autologous transplantation to provide hematopoietic stem cells after intensive chemoradiotherapy. However, PBSC which contain a large number of T cells represent a potential risk for graft-versus-host disease (GVHD) in allogeneic (allo) transplantation. There are about 50 case reports of clinical trials of rhG-CSF-mobilized allo PBSC transplantation (PBSCT) with relatively rapid hematological recovery, without severe acute GVHD except in a few cases. Therefore, the risk of inducing severe acute GVHD is not as high as was expected when allo PBSCT began. However, whether allo PBSCT will increase the risk of chronic GVHD is not clear, because the period of observation has been too short. Also, it will be of interest to determine the clinical effect of allo PBSCT on relapse of hematological malignancy post-transplant. Whether allo PBSCT will increase life-threatening acute and chronic GVHD, and whether PBSC allografting will result in permanent hematological and immunological reconstitution has to be determined by prospective randomized clinical trials.

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References

  1. Barr RD, Mcbride JA (1982) Haematopoietic engraftment with peripheral blood cells in the treatment of malignant disease. Br J Haematol 51:181–187

    Google Scholar 

  2. Bell AJ, Hamblin TJ, Oscier DG (1986) Circulating stem cells autograft. Bone Marrow Transplant 1:103–110

    Google Scholar 

  3. To LB, Juttner CA (1987) Peripheral blood stem cell autografting: a new therapeutic option for AML? Br J Haematol 66:285–288

    Google Scholar 

  4. Lowry PA, Tabbara IA (1992) Peripheral hematopoietic stem cell transplantation: current concepts. Exp Hematol 20:937–942

    Google Scholar 

  5. Gianni AM, Siena S, Bregni M, Tarella C, Stern AC, Pileri A, Bonadonna G (1989) Granulocyte-macrophage colony-stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation. Lancet 2:580–585

    Google Scholar 

  6. Molineux G, Pojda Z, Hampson IN, Lord BI, Dexter TM (1990) Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor. Blood 76:2153–2158

    Google Scholar 

  7. Sheridan WP, Begley CG, Juttner CA, Szer J, To LB, Maher D, McGrath KM, Morstyn G, Fox RM (1992) Effect of peripheral-blood progenitor cells mobilized by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy. Lancet 339:640–644

    Google Scholar 

  8. Neben S, Marcus K, Mauch P (1993) Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factor. Blood 81:1960–1967

    Google Scholar 

  9. Bensinger W, Singer J, Appelbaum F, Lilleby K, Longin K, Rowley S, Clarke E, Clift R, Hansen J, Shields T, Storb R, Weaver C, Weiden P, Buckner CD (1993) Autologous transplantation with peripheral blood mononuclear cells collected after administration of recombinant granulocyte stimulating factor. Blood 81:3158–3163

    Google Scholar 

  10. Russel NH, Hunter AE (1994) Peripheral blood stem cells for allogeneic transplantation. Bone Marrow Transplant 13:353–355

    Google Scholar 

  11. Micklem HS, Anderson N, Ross E (1975) Limited potential of circulating haematopoietic cells. Nature 256:41–43

    Google Scholar 

  12. Richman CM, Weiner RS, Yankee RA (1976) Increase in circulating stem cells following chemotherapy in man. Blood 47:1031–1039

    Google Scholar 

  13. Molineux G, Pojda Z, Hampson IN, Lord BI, Dexter TM (1990) Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor. Blood 76:2153–2158

    Google Scholar 

  14. Baumann I, Testa NG, Lange C, de Wynter E, Luft T, Dexter TM, van Hoef MEHM, Howell A (1993) Haemopoietic cells mobilized into the circulation by lenograstim as alternative to bone marrow for allogeneic transplants. Lancet 341:369

    Google Scholar 

  15. Weaver CH, Buckner CD, Longin K, Appelbaum FR, Rowley S, Lilleby K, Miser J, Storb R, Hansen JA, Beninger W (1993) Syngeneic transplantation with peripheral blood mononuclear cells collected after the administration of recombinant human granulocyte colony-stimulating factor. Blood 82:1981–1984

    Google Scholar 

  16. Dreger P, Haferlach T, Eckstein V, Jacobs S, Suttorp M, Loeffler H, Mueller-Ruchholtz W, Schmitz N (1994) G-CSF-mobilized peripheral blood progenitor cells for allogeneic transplantation: safety, kinetics of mobilization, and composition of the graft. Br J Haematol 87:609–613

    Google Scholar 

  17. Tjonnfjord GE, Steen R, Evensen SA, Thorsby E, Egeland T (1994) Characterization of CD34+ peripheral blood cells from healthy adults mobilized by recombinant human granulocyte colony-stimulating factor. Blood 84:2795–2801

    Google Scholar 

  18. Chatta GS, Price TH, Allen RC, Dale DC (1994) Effects of in vivo recombinant methionyl human granulocyte colony-stimulating factor on the neutrophil response and peripheral blood colony-forming cells in healthy young and elderly adult volunteers. Blood 84:2923–2929

    Google Scholar 

  19. Suzue T, Kawano Y, Takaue Y, Kuroda Y (1994) Cell processing protocol for allogeneic peripheral blood stem cells mobilized by granulocyte colony-stimulating factor. Exp Hematol 22:888–892

    Google Scholar 

  20. Schmitz N (1995) Allogeneic peripheral stem cell transplantation. Exp Hematol 23:742

    Google Scholar 

  21. Kessinger A, Smith DM, Standjord SE (1989) Allogeneic transplantation of blood-derived, T-cell-depleted hemopoietic stem cells after myeloablative treatment in a patient with acute lymphoblastic leukemia. Bone Marrow Transplant 4:643–646

    Google Scholar 

  22. Dreger P, Suttorp M, Haferlach T, Loeffler H, Schmitz N, Schroyens W (1993) Allogeneic granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells for treatment of engraftment failure after bone marrow transplantation. Blood 81:1404–1407

    Google Scholar 

  23. Russell NH, Hunter A, Rogers S, Hanley J, Anderson D (1993) Peripheral blood stem cells as an alternative to marrow for allogeneic transplantation. Lancet 341:1482

    Google Scholar 

  24. Nemunitis J, Rosenfeld C, Collins R, Pineiro L, Ohr S, Pallansch P, Schadduck R, Stone M, Fay J (1993) Pilot trial of allogeneic transplant combining peripheral blood and bone marrow in patients with refractory hematologic malignancy. Blood 82 [Suppl 1]: 417a

    Google Scholar 

  25. Tanaka J, Imamura M, Zhu X, Kobayashi S, Imai K, Hashino S, Sakurada K, Kasai M, Higa T (1994) Potential benefit of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood stem cells for allogeneic transplantation. Blood 84:3595–3596

    Google Scholar 

  26. Sasaki A, Tsukaguchi M, Hirai M, Ohira H, Kakao Y, Yamane T, Park K, Im T, Tatsumi N (1994) Transplantation of allogeneic peripheral blood stem cells after myeloablative treatment of a patient in blastic crisis of chronic myelocytic leukemia. Am J Hematol 47:45–49

    Google Scholar 

  27. Majolino I, Buscemi F, Scime R, Indovina A, Santoro A, Vesta S, Pampinella M, Catania P, Fabbiano F, Tringali S, Caronia F, Marceno R (1994) G-CSF mobilized PBSC for allogeneic transplantation. Blood 84 [Suppl 1]: 92a

    Google Scholar 

  28. Oblon DJ, Paul S, Oblon MB, Yankee R (1994) Allogeneic peripheral blood stem cell transplantation: preliminary results. Blood 84 [Suppl 1]: 94a

    Google Scholar 

  29. Bensinger WI, Weaver CH, Appelbaum FR, Rowley S, Demirer T, Sanders J, Storb R, Buckner CD (1995) Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor. Blood 85:1655–1658

    Google Scholar 

  30. Koerbling M, Przepiorka D, Huh YO, Engel H, van Besien K, Giralt S, Andersson B, Kleine HD, Seong D, Deisseroth AB, Andreeff M, Camplin R (1995) Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: potential advantage of blood over marrow allografts. Blood 85:1659–1665

    Google Scholar 

  31. Schmitz N, Dreger P, Suttorp M, Rohwedder EB, Haferlach T, Loeffler H, Hunter A, Russell NH (1995) Primary transplantation of allogeneic peripheral blood progenitor cells mobilized by filgrastim (granulocyte colony-stimulating factor). Blood 85:1666–1672

    Google Scholar 

  32. Ferrara JLM, Deeg HJ (1991) Graft versus host disease. N Engl J Med 324:667–674

    Google Scholar 

  33. Antin JH, Ferrara JLM (1992) Cytokine dysregulation and acute graft-versus-host disease. Blood 80:2964–2968

    Google Scholar 

  34. Ferrara JLM (1994) Paradigm shift for graft-versus-host disease. Bone Marrow Transplant 14:183

    Google Scholar 

  35. Tanaka J, Imamura M, Kasai M, Masauzi N, Watanabe M, Matsuura A, Morii K, Kiyama Y, Naohara T, Higa T, Honke K, Gasa S, Sakurada K, Miyazaki T (1993) Rapid analysis of tumor necrosis factor-alpha mRNA expression during venoocclusive disease of the liver after allogeneic bone marrow transplantation. Transplantation 55:430–432

    Google Scholar 

  36. Tanaka J, Imamura M, Kasai M, Masauzi N, Matsuura A, Ohizumi H, Morii K, Kiyama Y, Naohara T, Higa T, Sakurada K, Miyazaki T (1993) Cytokine gene expression in peripheral blood mononuclear cells during graft-versus-host disease after allogeneic bone marrow transplantation. Br J Haematol 85:558–565

    Google Scholar 

  37. Tanaka J, Imamura M, Kasai M, Kobayashi S, Hashino S, Kobayashi H, Sakurada K, Miyazaki T (1994) Cytokine gene expression in the mixed lymphocyte culture in allogeneic bone marrow transplantation as a predictive method for transplantation-related complications. Br J Haematol 87:415–418

    Google Scholar 

  38. Tanaka J, Imamura M, Kasai M, Zhu X, Kobayashi S, Imai K, Hashino S, Sakurada K, Miyazaki T (1994) Cytokine gene expression by concanavalin A-stimulated peripheral blood mononuclear cells after bone marrow transplantation: an indicator of immunological abnormality due to chronic graft-versus-host disease. Bone Marrow Transplant 14:695–701

    Google Scholar 

  39. Tanaka J, Imamura M, Kasai M, Sakurada K, Miyazaki T (1995) Cytokine gene expression after allogeneic bone marrow transplantation. Leuk Lymph 16:413–418

    Google Scholar 

  40. Theobald M, Nierle T, Bunles D, Arnold R, Heimpel H (1992) Host-specific interleukin-2-secreting donor T-cell precursors as predictors of acute graft-versus-host disease in bone marrow transplantation between HLA-identical siblings. N Engl J Med 327:1613–1617

    Google Scholar 

  41. Waldmann H, Polliak A, Hale G, Or R, Cividalli G, Weiss L, Weshler Z, Samuel S, Manor D, Brautbar C, Rachmilewitz EA, Slavin S (1984) Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). Lancet 2:483–485

    Google Scholar 

  42. Wagner JE, Donnenberg AD, Noga SJ, Cremo CA, Gao IK, Yin HJ, Vogelsang GB, Rowley S, Saral R, Santos GW (1988) Lymphocyte depletion of donor bone marrow by counterflow centrifugal elutriation: results of a phase-I clinical trial. Blood 72:1168–1176

    Google Scholar 

  43. Young JW, Papadopoulos EB, Cunningham I, Castro-Malaspina H, Flomenberg N, Carabasi MH, Gulati SC, Brochstein JA, Heller G, Black P, Collins NH, Shank B, Kernan NA, O'Reilly RJ (1992) T-cell-depleted allogeneic bone marrow transplantation in adults with acute nonlymphocytic leukemia in first remission. Blood 79:3380–3387

    Google Scholar 

  44. Dreger P, Viehmann K, Steinmann J, Eckstein V, Mueller-Ruchholtz W, Loeffler H, Schmitz N (1995) G-CSF-mobilized peripheral blood progenitor cells for allogeneic transplantation: comparison of T-cell-depletion strategies using different CD34+ selection systems or CAMPATH-1. Exp Hematol 23:147–154

    Google Scholar 

  45. Negrin RS. Kusnierz-Glaz CR, Still BJ, Schriber JR, Chao NJ, Long GD, Hoyle C, Hu WW, Horning SJ, Brown BW, Blume KG, Strober S (1995) Transplantation of enriched and purged peripheral blood progenitor cells from a single apheresis product in patients with non-Hodgkin's lymphoma. Blood 85:3334–3341

    Google Scholar 

  46. Schiller G, Vescio R, Freytes C, Spitzer G, Sahebi F, Lee M, Wu CH, Cao J, Lee JC, Hong CH, Lichtenstein A, Lill M, Hall J, Berenson R, Berenson J (1995) Transplantation of CD34+ peripheral blood progenitor cells after high-dose chemotherapy for patients with advanced multiple myeloma. Blood 86:390–397

    Google Scholar 

  47. de Revel T, Appelbaum FR, Storb R, Schuening F, Nash R, Deeg J, McNiece I, Andrews R, Graham T (1994) Effects of granulocyte colony-stimulating factor and stem cell factor, alone and in combination, on the mobilization of peripheral blood cells that engraft lethally irradiated dogs. Blood 83:3795–3799

    Google Scholar 

  48. Lane TA, Law P, Maruyama M, Young D, Burgess J, Mullen M, Mealiffe M, Terstappen LWMM, Hardwick A, Moubayed M, Oldham F, Corringham RET, Ho AD (1995) Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by granulocytemacrophage colony-stimulating factor (GM-CSF) or G-CSF: potential role in allogeneic marrow transplantation. Blood 85:275–282

    Google Scholar 

  49. Pettengell R, Luft T, de Wynter E, Coutinho L, Young R, Fitzsimmons L, Scarffe JH, Testa NG (1995) Effects of interleukin-6 on mobilization of primitive haemopoietic cells into the circulation. Br J Haematol 89:237–242

    Google Scholar 

  50. Brugger W, Moecklin W, Heimfeld S, Berenson RJ, Mertelsmann R, Kanz L (1993) Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, interleukin-1β (IL-1β), IL-6, IL-3, interferon-γ, and erythropoietin. Blood 81:2579–2584

    Google Scholar 

  51. Sullivan KM, Storb R, Buckner CD, Fefer A, Fisher L, Weiden PL, Witherspoon RP, Appelbaum FR, Banaji M, Hansen J, Martin P, Sanders JE, Singer J, Thomas ED (1989) Graftversus-host disease as adoptive immunotherapy in patients with advanced hematologic neoplasms. N Engl J Med 320:828–834

    Google Scholar 

  52. Johnson BD, Truitt RL (1995) Delayed infusion of immuno-competent donor cells after bone marrow transplantation breaks graft-host tolerance and allows for persistent antileukemic reactivity without severe graft-versus-host disease. Blood 85:3302–3312

    Google Scholar 

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Authors and Affiliations

  1. Third Department of Internal Medicine, Hokkaido University School of Medicine, N15 W7, Kita-ku, 060, Sapporo, Japan

    J. Tanaka, M. Imamura & M. Asaka

  2. Department of Internal Medicine, Sapporo Hokuyu Hospital, Higashi Sapporo 6-6, Shiroishi-ku, 003, Sapporo, Japan

    M. Kasai

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Tanaka, J., Kasai, M., Imamura, M. et al. Clinical application of allogeneic peripheral blood stem cells transplantation. Ann Hematol 71, 265–269 (1995). https://doi.org/10.1007/BF01697977

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  • DOI: https://doi.org/10.1007/BF01697977

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