Summary
The therapeutic results of Lp-TAE (transcatheter arterial embolization in the presence or absence of Gelfoam particles preceded by the infusion of a mixture of lipiodol and an anticancer drug via the proper hepatic artery) or DSM-TAE (transcatheter arterial embolization with degradable starch microspheres and the arterial injection of anticancer drugs via the hepatic artery) combined with hyperthermia were evaluated in 30 patients with hepatocellular carcinoma (HCC), 5 subjects with hepatic cholangiocarcinoma, and 22 patients with metastatic liver carcinoma. Hyperthermia was performed using an 8-MHz Thermotron RF-8. Tumor temperatures could be measured in 31 patients (54.4%) with malignant lesions of the liver who had undergone hyperthermia. The mean maximal temperature (Tmax) was 41.5°C in the metastatic liver cancers. The efficiency of heating in HCC was unfavorable, i.e., the mean Tmax was only 40.7 °C. The rise in tumor temperature was greater in either HCC or metastatic liver carcinoma associated with portal invasion of the lesion. The tumor-temperature elevation was also excellent in HCC that had been subjected to embolization with DSM in combination with hyperthermia. The response rate (complete response plus partial response) was as high as 40% (4/10) in the group in which the tumor temperature could be raised to 42°C or more. Among the 52 patients who had shown a high pretreatment level of tumor marker, that value decreased in 34 cases (65.4%), and the decrease was greater than 50% in 22 cases (42.3%).
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Arosen KF, Hellekant C, Holmberg J, Rothman U, Teder H (1979) Controlled blocking of hepatic artery flow with enzymatically degradable microspheres combined with oncolytic drugs. Eur Surg Res 11: 99
Carlsson G, Ekelund L, Hafström L, Jonsson N, Stigsson L (1981) Effects of hepatic artery ligation and intraarterial embolization on liver tumor growth — an experimental study in rats. J Surg Oncol 17: 249
Carlsson G, Hafström L, Hugander A, Jönsson PE, Bolmsjo M, Persson B (1983) The effect of total body microwave hyperthermia and hepatic artery ligation on liver tumors — an experimental study in rats. J Surg Oncol 22: 37
Dakhil S, Ensminger W, Cho K, Niederhuber J, Doan K, Wheeler R (1982) Improved regional selectivity of hepatic arterial BCNU with degradable microspheres. Cancer 50: 631
Emami B, Nussbaum GH, Hahn N, Piro AJ, Dritschilo A, Quimby F (1981) Histopathological study on the effects of hyperthermia on microvasculature. Int J Radiat Oncol Biol Phys 7: 343
Erichsen C (1985) Blockage of the hepatic-artery blood flow by biodegradable microspheres (Spherex) combined with local hyperthermia in the treatment of experimental liver tumors in rats. J Cancer Res Clin Oncol 109: 38
Forsberg JO, Jung B, Larsson B (1978) Mucosal protection during irradiation of exteriorized rat ileum. Effect of hypoxia induced by starch microspheres. Acta Radiol Oncol 17: 485
Lindell B, Aronsen KF, Nosslin B, Rothman U (1978) Studies in pharmacokinetics and tolerance of substances temporarily retained in the liver by microsphere embolization., Ann Surg 187: 95
Moffat FL, Gilas T, Calhoun K, Falk M, Dalfen R, Rotstein LE, Makowka L, Howard V, Laing D, Venturi D, Langer JC, Falk JA, Falk RE (1985) Further experience with regional radiofrequency hyperthermia and cytotoxic chemotherapy for unresectable hepatic neoplasia. Cancer 55: 1291
Patterson J, Strang R (1979) The role of blood flow in hyperthermia. Int J Radiat Oncol Biol Phys 5: 235
Pfeifle CE, Howell SB, Bookstein JJ (1985) Pilot study of intra-arterial fluorouridine, mitomycin and doxorubicin in combination with degradable starch microspheres to treat primary and metastatic tumors of the liver. Cancer Drug Deliv 2: 305
Song CW (1978) Effect of hyperthermia on vascular functions of normal tissues and experimental tumors; brief communication. J Natl Cancer Inst 60: 711
Strom FK, Baker HW, Scanlon EF, Plenk HP, Meadows PM, Cohen SC, Olson, CE, Thomson JW, Khandekar JD, Roe D, Nizze A, Morton DL (1985) Magnetic induction hyperthermia; results of a 5-year multi-institutional national cooperative trial in advanced cancer patients. Cancer 55: 2677
Tanaka Y, Hasegawa T, Akagi K (1981) Effects of hyperthermia combined with radiation on normal and tumor microcirculation. In: Fundamentals of cancer therapy by hyperthermia, radiation and chemicals. Mag Bros., Tokyo, p 95
Ziessman HA, Thrall JH, Gyves JW, Ensminger WD, Niederhuber JE, Tuscan M, Walker S (1983) Quantitative hepatic arterial perfusion scintigraphy and starch microspheres in cancer chemotherapy. J Nucl Med 24: 871
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Tanaka, Y., Yamamoto, K., Murata, T. et al. Effects of multimodal treatment and hyperthermia on hepatic tumors. Cancer Chemother. Pharmacol. 31 (Suppl 1), S111–S114 (1992). https://doi.org/10.1007/BF00687119
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DOI: https://doi.org/10.1007/BF00687119