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Prednimustine and vincristine compared with cytosine arabinoside and thioguanine for treatment of elderly patients with acute nonlymphoblastic leukemia

  • Original Articles
  • Vincristine and Prednimustine ANLL in Elderly Patients Ara-C-6-TG
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Summary

Sixty-seven patients with acute nonlymphoblastic leukemia (ANLL) and above the age of 60 years were randomly allocated to treatment with either prednimustine+vincristine or cycles with cytosine arabinoside and thioguanine. Of the 67 patients, 13 (19%) entered a complete remission and four a partial remission. Of 33 patients randomized to prednimustine and vincristine (15 adequately treated), three entered a complete remission and one a partial remission. Four further patients went into complete remission after a switch to other treatment modalities. Of 34 patients randomized to cycles of ARA-C and thioguanine (22 adequately treated), four entered a complete remission and three a partial remission with the correct program. One patient entered a remission with intermittent cytosine arabinoside+thioguanine (wrong program) and one further patient entered a complete remission after a switch to prednimustine and vincristine. Prednimustine+vincristine did not appear to be superior to treatment with cytosine arabinoside thioguanine cycles for elderly patients with ANLL.

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Authors and Affiliations

  1. Department of Medicine, Huddinge Hospital, S-141 86, Huddinge

    Berit Lönnqvist, Gösta Gahrton, Dieter Lockner & Christer Paul

  2. Danderyds Hospital, S-141 86, Stockholm

    Magnus Björkholm

  3. Karolinska Hospital, S-141 86, Stockholm

    Börje Andersson, Robert Hast & Bo Lantz

  4. South Hospital Stockholm, Stockholm, Sweden

    Lars Engstedt, Jan Palmblad & Ann-Mari Udén

  5. Regional Hospital, S-141 86, Örebro

    Ann-Marie Stalfelt & Bengt Wadman

  6. University Hospital Uppsala, Uppsala, Sweden

    Andreas Killander, Bengt Simonsson & Gunnar Öberg

  7. Department of Clinical Immunology, Huddinge Hospital, S-141 86, Huddinge

    Göran Holm

  8. Radiumhemmet, Karolinska Hospital, S-141 86, Stockholm

    Håkan Mellstedt

  9. Department of Pharmacology, Karolinska Institute, S-141 86, Stockholm, Sweden

    Curt Peterson

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  1. Berit Lönnqvist
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  2. Börje Andersson
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  12. Jan Palmblad
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  13. Christer Paul
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  14. Curt Peterson
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  15. Bengt Simonsson
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  16. Ann-Marie Stalfelt
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  17. Ann-Mari Udén
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  19. Gunnar Öberg
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Lönnqvist, B., Andersson, B., Björkholm, M. et al. Prednimustine and vincristine compared with cytosine arabinoside and thioguanine for treatment of elderly patients with acute nonlymphoblastic leukemia. Cancer Chemother. Pharmacol. 9, 89–92 (1982). https://doi.org/10.1007/BF00265385

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  • DOI: https://doi.org/10.1007/BF00265385

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