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Association of class I, II, and III MHC gene products with systemic lupus erythematosus

Results of a central european multicenter study

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Summary

Class I, II, and III MHC gene products were examined in 248 Central European SLE patients. The previously reported association with HLA-A1, -B8 and -DR3, and C4AQ0 alleles was confirmed. The frequency of HLA-DR2 was also slightly elevated in SLE patients, while no increase in C4BQ0 alleles was observed. Additional findings were a significantly increased frequency of HLA-B13 and a significant decrease of HLA-B44.

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Authors and Affiliations

  1. Departments of Medicine and Immunology and Blood Bank, Universities of Bern, Switzerland

    W. J. Pichler

  2. Department of Medicine and Immunology and Blood Bank, Universities of Frankfurt, Federal Republic of Germany

    H. Krippner & K. Jörgens

  3. Departments of Medicine and Immunology and Blood Bank, Universities of Freiburg, Federal Republic of Germany

    B. Lang & H. H. Peter

  4. Departments of Medicine and Immunology and Blood Bank, Universities of Hannover, Federal Republic of Germany

    K. Hartung, M. Klar, M. Robin-Winn & H. Deicher

  5. Departments of Medicine and Immunology and Blood Bank, Universities of München, Federal Republic of Germany

    D. Schendel

  6. Departments of Medicine and Immunology and Blood Bank, Universities of Zürich, Switzerland

    A. Fontana

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  1. K. Hartung
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  2. A. Fontana
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  3. M. Klar
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  4. H. Krippner
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  5. K. Jörgens
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  6. B. Lang
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  7. H. H. Peter
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  8. W. J. Pichler
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  10. M. Robin-Winn
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Hartung, K., Fontana, A., Klar, M. et al. Association of class I, II, and III MHC gene products with systemic lupus erythematosus. Rheumatol Int 9, 13–18 (1989). https://doi.org/10.1007/BF00270284

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  • DOI: https://doi.org/10.1007/BF00270284

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