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Ultrasound-guided percutaneous laser ablation of liver tissue in a rabbit model

  • Original Articles
  • Ultrasound Radiology
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Abstract

The present report evaluates the efficacy and safety of percutaneous interstitial laser tissue ablation of the liver in nine New Zealand rabbits. A Nd: YAG laser was coupled to a quartz fibreoptic guide (600 μm) with a flat tip. The fibre and a thermocouple were placed in the lumen of two Chiba needles (18G) and these were inserted into the liver 10 mm apart under ultrasound guidance. The laser was fired for 5 min at 1, 3 and 5 W power, respectively, in three groups of rabbits. There were no acute complications and all the rabbits except one survived until the established time of sacrifice. The procedure induced a cavity surrounded by a zone (about 10 mm) of coagulative necrosis. After 2 weeks a strong peripheral inflammatory response was evident and after 4 weeks a capsule of connective tissue enclosed the lesions. Our study seems to offer a safe and rapid technique producing a “guaranteed kill radius” for the treatment of small hepatic neoplasms.

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Authors and Affiliations

  1. Ospedale Regina Apostolorum, V. San Francesco 50, 00041, Albano Laziale, Roma, Italy

    C. M. Pacella, Z. Rossi, G. Bizzarri & E. Papini

  2. Istituto di Biopatologia Umana, Universitá “La Sapienza”, Viale Regina Elena, 00161, Roma, Italy

    V. Marinozzi & D. Paliotta

  3. Istituto di Clinica Chirurgica, Universitá “La Sapienza”, Viale Regina Elena, 00161, Roma, Italy

    P. Castaldo & V. Ziparo

  4. ENEA, V. E. Fermi 13, 00040, Frascati, Roma, Italy

    F. Garosi & M. Cinti

  5. Electronic Engineering, V. San Giovanni 10, Firenze, Italy

    F. Muzzi

Authors
  1. C. M. Pacella
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  2. Z. Rossi
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  3. G. Bizzarri
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  4. E. Papini
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  5. V. Marinozzi
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  6. D. Paliotta
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  7. P. Castaldo
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  8. V. Ziparo
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  9. F. Garosi
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  10. M. Cinti
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  11. F. Muzzi
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Correspondence to: C. M. Pacella

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Pacella, C.M., Rossi, Z., Bizzarri, G. et al. Ultrasound-guided percutaneous laser ablation of liver tissue in a rabbit model. Eur. Radiol. 3, 26–32 (1993). https://doi.org/10.1007/BF00173518

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  • DOI: https://doi.org/10.1007/BF00173518

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